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Table of Contents
Vol. 41, No. 4, 1996
Issue release date: 1996
Section title: Original Paper
Gynecol Obstet Invest 1996;41:253–259
(DOI:10.1159/000292280)

Cervical Cotinine and Macrophage Langerhans Cell Density in the Normal Human Uterine Cervix

Poppe W.A.J.a · Peeters R.b · Drijkoningen M.a · Ide P.S.a · Daenens P.b · Lauweryns J.M.a · van Assche F.A.a
aDepartments of Obstetrics and Gynaecology, and Pathology, University Hospital St. Rafael-Gasthuisberg, and bLaboratory of Toxicology, Faculty of Pharmaceutical Sciences, Catholic University of Leuven, Leuven, Belgium

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 26, 1995
Accepted: September 20, 1995
Published online: March 01, 2010
Issue release date: 1996

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI

Abstract

Cotinine levels in blood and cervical fluid of smokers and non-smokers were analysed using capillary-column gas chromatography. These levels were not related to numerical cell densities of intraepithelial S100-protein- and LN2-positive Langerhans cells or to MAC-387-positive macrophages in the stroma of the transformation zone of normal uterine cervices. A decrease in the number of Langerhans cells was noted in smokers, especially in those using oral contraceptives (OCs). Macrophages were more numerous in the endocervical stroma of smokers, suggesting a local response to smoke constituents. These findings may indicate a synergistic suppression of local cervical immunity by smoking and OCs.

© 1996 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 26, 1995
Accepted: September 20, 1995
Published online: March 01, 2010
Issue release date: 1996

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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