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Vol. 40, No. 2, 1995
Issue release date: 1995
Section title: Original Paper
Gynecol Obstet Invest 1995;40:125–128
(DOI:10.1159/000292320)

Clinical Effects of Preoperative Oestradiol Treatment before Vaginal Repair Operation

A Double-Blind, Randomized Trial

Mikkelsen A.L.a · Felding C.b · Clausen H.V.b
aDepartment of Obstetrics and Gynaecology, University of Copenhagen, Gentofte County Hospital, Hellerup, and bDepartment of Obstetrics and Gynaecology, University of Copenhagen, Glostrup County Hospital, Glostrup, Denmark

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/15/1994
Accepted: 2/6/1995
Published online: 3/1/2010
Issue release date: 1995

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI

Abstract

The objective of the study was to assess the effects of low-dose vaginal treatment with oestradiol before vaginal operation. In a double-blind randomized study including 43 postmenopausal women scheduled for vaginal repair operation for genital descensus, it was found that 7 patients suffered from concomitant urinary stress incontinence. Vagifem® (25 μg oestradiol) or placebo was administered as vaginal pessaries daily, 3 weeks prior to surgery and the clinical effects evaluated. One month postoperatively the prevalence of bacteriuria ( > 100,000 CFU/ml urine) was significantly lower when using oestradiol than in the placebo group. At follow-up 3 years later 40 women (93%) answered the questionnaires. None received hormone replacement therapy. Nineteen percent in the preoperative oestradiol group and 11% in the preoperative placebo group had had more than two episodes of cystitis treated with antibiotics. This difference is not statistically significant (p > 0.05). Recurrent cystitis was not correlated to bacteriuria postoperatively. Seventy-nine percent of the women with genital prolapse but only 29% of the women with concomitant urinary stress incontinence were cured (p < 0.05). Neither preoperative oestradiol treatment nor body weight had any influence on relapse. Preoperative low-dose vaginal oestradiol treatment may reduce the incidence of bacteriuria in the immediate postoperative period but no long-lasting effects on recurrent cystitis or relapse were seen. Longer-lasting hormone replacement therapy may be necessary to achieve lasting effects.

© 1995 S. Karger AG, Basel


  

Author Contacts

Anne Lis Mikkelsen, MD, Steen Blichersvej 5, DK-2000 Frederiksberg (Denmark)

  

Article Information

Received: June 15, 1994
Accepted after revision: February 6, 1995
Published online: March 01, 2010
Number of Print Pages : 4

  

Publication Details

Gynecologic and Obstetric Investigation

Vol. 40, No. 2, Year 1995 (Cover Date: 1995)

Journal Editor: D'Hooghe T. (Leuven)
ISSN: 0378-7346 (Print), eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/15/1994
Accepted: 2/6/1995
Published online: 3/1/2010
Issue release date: 1995

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


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