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Vol. 39, No. 4, 1995
Issue release date: 1995
Section title: Original Paper
Gynecol Obstet Invest 1995;39:234–238
(DOI:10.1159/000292417)

Increased Concentrations of Lactate Dehydrogenase in Pregnancy with Preeclampsia: A Predictor for the Birth of Small-for-Gestational-Age Infants

He S. · Bremme K. · Kallner A. · Blombäck M.
aDepartment of Laboratory Medicine/ Blood Coagulation Research, and bDepartment of Obstetrics and Gynecology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/13/1994
Accepted: 10/14/1994
Published online: 3/1/2010

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI

Abstract

Lactate dehydrogenase (LDH), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) concentrations and platelet counts were measured in 26 normal pregnant women and 51 preeclamptic women. In the normal-pregnancy group, no significant changes were found in the results of these tests. In the preeclampsia group, ALT and AST concentrations were not significantly higher than those in normal pregnancy, but the LDH concentrations increased and the platelet counts decreased significantly through the pregnancy. The increases in LDH did not correlate with changes in ALT or AST. Preeclamptic women with small-for-gestational-age (SGA) infants had significantly higher LDH concentrations than those in the appropriate-for-gestational-age (AGA) group, but ALT and AST concentrations did not increase significantly. As reasons for the LDH increase in our subjects, liver damage was excluded and more active glycolysis in addition to severe cell damage due to chronic anoxemia were inferred. It is suggested that an increase in LDH is predictive of SGA infants in preeclamptic pregnancy, especially in those with normal liver function.


  

Author Contacts

Katarina Bremme, MD, Department of Obstetrics and Gynecology, Karolinska Hospital, S-171 76 Stockholm (Sweden)

  

Article Information

Received: September 13, 1994
Accepted: October 14, 1994
Published online: March 01, 2010
Number of Print Pages : 5

  

Publication Details

Gynecologic and Obstetric Investigation

Vol. 39, No. 4, Year 1995 (Cover Date: 1995)

Journal Editor: D'Hooghe T. (Leuven)
ISSN: 0378-7346 (Print), eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/13/1994
Accepted: 10/14/1994
Published online: 3/1/2010

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


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