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Vol. 128, No. 1-3, 2010
Issue release date: May 2010
Section title: Paper
Cytogenet Genome Res 2010;128:37–45
(DOI:10.1159/000293923)

New Ventures in the Genotoxic and Cytotoxic Effects of Macrocyclic Lactones, Abamectin and Ivermectin

Molinari G. · Soloneski S. · Larramendy M.L.
Cátedra de Citología, Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata, La Plata, Argentina

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 4/9/2010
Issue release date: May 2010

Number of Print Pages: 9
Number of Figures: 1
Number of Tables: 2

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Abamectin and Ivermectin are 2 closely related members of the Avermectin family of 16-membered macrocyclic lactones derived from the actinomycete Streptomyces avermectinius which exhibit extraordinary anthelmintic activity. They are used worldwide in veterinary and human medicine as well as in agriculture. In the present review we summarized the results published so far for estimating the genotoxicity and cytotoxicity exerted by both compounds in several cellular systems. Although both compounds do not induce in vitro and in vivo gene mutations in either bacterial or mammalian cells, there is no concrete evidence of a clear clastogenic effect exerted both in vitro and in vivo in mammalian cells. However, reports indicating that both anthelmintic agents are able to induce single DNA-strand breaks in vitro and inhibit cell growth either in vitro or in in vivo bioassays, are scarce. Taking into account the similarity of the genotoxicity and cytotoxicity exerted by both antibiotics, and that only Abamectin has been classified so far as a class II toxicity pesticide by the EPA, the necessity of reconsideration for a further hazard evaluation of Ivermectin by an international regulatory agency(ies) is strongly recommended.


  

Author Contacts

Marcelo L. Larramendy, PhD
Cátedra de Citología
Facultad de Ciencias Naturales y Museo
Calle 64 No. 3, La Plata 1900 (Argentina)
Tel. +54 221 424 9049, Fax +54 221 425 8252, E-Mail m_larramendy@hotmail.com

  

Article Information

Published online: April 9, 2010
Number of Print Pages : 9
Number of Figures : 1, Number of Tables : 2, Number of References : 69

  

Publication Details

Cytogenetic and Genome Research

Vol. 128, No. 1-3, Year 2010 (Cover Date: May 2010)

Journal Editor: Schmid M. (Würzburg)
ISSN: 1424-8581 (Print), eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 4/9/2010
Issue release date: May 2010

Number of Print Pages: 9
Number of Figures: 1
Number of Tables: 2

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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