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Dietary Linoleic Acid and Glucose Enhances Azoxymethane-Induced Colon Cancer and Metastases via the Expression of High-Mobility Group Box 1Ohmori H. · Luo Y. · Fujii K. · Sasahira T. · Shimomoto T. · Denda A. · Kuniyasu H.
Department of Molecular Pathology, Nara Medical University, Kashihara, Japan Corresponding Author
Dr. Hiroki Kuniyasu
Department of Molecular Pathology, Nara Medical University
Kashihara, Nara 634-8521 (Japan)
Tel. +81 74 422 3051, Fax +81 74 425 7308, E-Mail email@example.com
Objective: High-mobility group box 1 (HMGB1) was closely associated with progression and metastasis of colorectal cancer. Methods: We examined the significance of HMGB1 in causing colon carcinogenesis induced by azoxymethane (AOM) injection in Fischer 344 rats fed on a control diet (group C), a 15% linoleic acid (LA) diet (group L), a control diet with 10% glucose drink (group G), and a 15% LA diet with a 10% glucose drink (group L+G). Results: Group L+G showed the highest body weight and calorie intake. Serum and mucosal HMGB1 levels were temporally increased in all groups, while the highest levels were observed in group L+G. Mucosal HMGB1 levels were correlated with cancer multiplicity and nodal metastases. In the AOM-injected rats fed the 15% LA diet with 10% glucose drink, administration of HMGB1 antibody suppressed serum HMGB1 concentration and cancer multiplicity . Conclusion: These data suggest that dietary LA and glucose provided the synergistic effect on AOM-induced rat colon cancer through HMGB1 induction.
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