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Vol. 5, No. 2, 2010
Issue release date: April 2010
Section title: Review Article · Übersichtsarbeit
Free Access
Breast Care 2010;5:86–90
(DOI:10.1159/000298962)

NHERF1/EBP50 in Breast Cancer: Clinical Perspectives

Bellizzi A. · Malfettone A. · Cardone R.A. · Mangia A.
a Clinical Experimental Oncology Laboratory, National Cancer Centre, Bari, b Department of General and Environmental Physiology, University of Bari, Italy, Both authors equally contributed to this work.

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Abstract

Na+/H+ exchanger regulatory factor 1 (NHERF1) is a postsynaptic density 95/disc-large/zona occludens (PDZ) domain-containing protein that recruits membrane receptors/transporters and cytoplasmic signaling proteins into functional complexes. NHERF1 expression has been demonstrated to be altered in breast cancer, but its role in mammary cancerogenesis and progression remains still undefined. In this paper, we review what is known on the pathological role and the potential clinical application of NHERF1 protein in breast cancer. Recent evidence shows that an increased cytoplasmic expression of NHERF1 suggests a key role of its localization/compartmentalization in defining cancerogenesis, progression, and invasion. NHERF1 overexpression is associated with increasing tumor cytohistological grade, aggressive clinical behavior, unfavorable prognosis, and increased tumor hypoxia. Moreover, NHERF1 co-localizes with the oncogenic receptor HER2/neu in HER2/neu-overexpressing carcinoma and in distant metastases. These data make NHERF1 also a potential candidate of clinical relevance for anti-HER2/neu therapy.


  

Author Contacts

Anita Mangia, PhD, Clinical Experimental Oncology Laboratory, National Cancer Centre, Via Hahnemann, 10, 70126 Bari, Italy, Tel. +39 0805555527, a.mangia@oncologico.bari.it

  

Article Information

Published online: April 9, 2010
Number of Print Pages : 5

  

Publication Details

Breast Care (Multidisciplinary Journal for Research, Diagnosis and Therapy)

Vol. 5, No. 2, Year 2010 (Cover Date: April 2010)

Journal Editor: Harbeck N. (Köln), Jakesz R. (Wien), Thomssen C. (Halle/Saale)
ISSN: 1661-3791 (Print), eISSN: 1661-3805 (Online)

For additional information: http://www.karger.com/BRC


Article / Publication Details

First-Page Preview
Abstract of Review Article · Übersichtsarbeit

Published online: 4/9/2010

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-3791 (Print)
eISSN: 1661-3805 (Online)

For additional information: http://www.karger.com/BRC


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