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Vol. 18, No. 2, 1984
Issue release date: 1984
Section title: Original Paper
Gynecol Obstet Invest 1984;18:88–94
(DOI:10.1159/000299055)

Histochemical Localization of Pregnancy-Associated Plasma Protein A in Fetal, Infant, and Adult Organs and Comparison between Antisera

Schindler A.-M.a · Bischof P.b
aCentre de cytologie et de dépistage du cancer et bDépartement de gynécologie et obstétrique, Hôpital cantonal universitaire, Genéve, Suisse

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/5/1983
Accepted: 3/1/1984
Published online: 3/15/2010
Issue release date: 1984

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI

Abstract

Histochemical localization of pregnancy-associated plasma protein A (PAPP A) was performed on various genital and extragenital organs from fetuses, infants, and adults. Three types of PAPP A reactive cells were found: endocrine, epithelial, and hematopoietic cells. Positive endocrine organs included the decidua and the fetal adrenal and Leydig cells. Positive epithelial cells were found in actively proliferating tissues, such as fetal renal tubules, fetal intestinal mucosa, and adult proliferative endometrial glands. In bone marrow, red cell precursors were PAPP A positive. Comparison of a commercially available antiserum with one raised in our own laboratory revealed significant differences in histochemical staining. The biological relevance of these findings remains to be determined.

© 1984 S. Karger AG, Basel


  

Author Contacts

Dr. Anne-Marie Schindler, Centre de cytologie et de dépistage du cancer, 51 bd de la Cluse, CH-1205 Genéve (Switzerland)

  

Article Information

Received: December 5, 1983
Accepted: March 1, 1984
Published online: March 15, 2010
Number of Print Pages : 7

  

Publication Details

Gynecologic and Obstetric Investigation

Vol. 18, No. 2, Year 1984 (Cover Date: 1984)

Journal Editor: D'Hooghe T. (Leuven)
ISSN: 0378-7346 (Print), eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/5/1983
Accepted: 3/1/1984
Published online: 3/15/2010
Issue release date: 1984

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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