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Vol. 13, No. 5, 2000
Issue release date: September–October 2000
Section title: Review
Skin Pharmacol Appl Skin Physiol 2000;13:229–234
(DOI:10.1159/000029928)

The Pig as an Experimental Animal Model of Percutaneous Permeation in Man: Qualitative and Quantitative Observations – An Overview

Simon G.A. · Maibach H.I.
Department of Dermatology, UCSF Medical School, San Francisco, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 8/11/2000

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

The pig has been a well-recognized experimental animal in biomedical research for many centuries. Physiological and anatomical similarities between man and pig made this animal a good model for man in many research areas. Pharmacological and toxicological research on the skin is often based on knowledge of skin absorption and percutaneous permeation. Anatomical, physiological and biochemical similarities are cited and various uses of the pig as a model for man in the investigation of skin permeation are reviewed. Further, several isolated organ models are reviewed. The importance of full details of the experimental animal, namely its age, sex, breed, size (weight) and body region, is emphasized.


  

Author Contacts

Dr. Gad A. Simon
Department of Pharmacology
Israel Institute for Biological Research, PO Box 19
IL–74100 Ness Ziona (Israel)
Tel. +972 8 938 1611, Fax +972 8 938 1519, E-Mail simon@iibr.gov.il

  

Article Information

Received: Received: Dec. 3, 1999
Accepted: March 30, 2000
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 2, Number of References : 59

  

Publication Details

Skin Pharmacology and Applied Skin Physiology (Journal of Pharmacological and Biophysical Research)
Incorporating ‘Bioengineering and the Skin’; Founded in 1988 by H. Schaefer
Official Journal of the Skin Pharmacology Society (SPS)

Vol. 13, No. 5, Year 2000 (Cover Date: September-October 2000)

Journal Editor: Hans F. Merk, Aachen
ISSN: 1422–2868 (print), 1422–2906 (Online)

For additional information: http://www.karger.com/journals/sph


Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 8/11/2000

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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