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Table of Contents
Vol. 33, No. 2, 2010
Issue release date: June 2010
Section title: Review
Free Access
Kidney Blood Press Res 2010;33:100–110

Alterations of Lipid Metabolism in Chronic Nephropathies: Mechanisms, Diagnosis and Treatment

Lacquaniti A. · Bolignano D. · Donato V. · Bono C. · Fazio M.R. · Buemi M.
Section of Nephrology, Department of Internal Medicine, University of Messina, Messina, Italy
email Corresponding Author

Prof. Michele Buemi

Via Salita Villa Contino, 30

IT–98100 Messina (Italy)

Tel. +39 090 221 2265, Fax +39 090 293 5162

E-Mail buemim@unime.it

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Nephropathic subjects show an increased tendency to develop cardiovascular diseases, mainly as the consequence of several risk factors including increased oxidative stress, inflammation, physical inactivity, anemia, vascular calcification, and endothelial dysfunction. The alterations in lipid metabolism represent a relatively lesser important cause of genesis and progression of atherosclerosis. Unfortunately, in these patients the atherogenic potential of dyslipidemia may depend more on apolipoproteins than on lipid abnormalities, and may not always be recognized by measurement of plasma lipids alone. The aim of this review was therefore to analyze the main lipid alterations that can occur in nephropathic patients, as well as their causes and their effects on the cardiovascular system. The clinical evidence and recommendations for the use of lipid-regulating drugs in patients with chronic kidney disease, nephrotic syndrome, in patients undergoing hemo- and peritoneal dialysis and in transplanted patients was also reviewed. Moreover, we analyzed the link between dyslipidemia and kidney disease onset and progression and the role of statins in preventing it.

© 2010 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Review

Published online: March 27, 2010
Issue release date: June 2010

Number of Print Pages: 11
Number of Figures: 3
Number of Tables: 1

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

For additional information: http://www.karger.com/KBR

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