Update of the Atlanta Classification of Severity of Acute Pancreatitis: Should a Moderate Category Be Included?de-Madaria E. · Soler-Sala G. · Lopez-Font I. · Zapater P. · Martínez J. · Gómez-Escolar L. · Sánchez-Fortún C. · Sempere L. · Pérez-López J. · Lluís F. · Pérez-Mateo M.
aUnidad de Gastroenterología, bServicio de Farmacología Clínica, y cServicio de Cirugía General, Hospital General Universitario de Alicante, Alicante, España
Background: Persistent and multiple organ failure (POF and MOF) are predictive of death in acute pancreatitis (AP). Local complications without organ failure are associated with morbidity but a low risk of mortality. Aim: To design a three-category classification of AP severity and to compare it with the Atlanta Classification (AC) in terms of morbidity and mortality. Method: Severe AP was defined as death, POF (>48 h) or MOF. Moderate AP was defined as the presence of acute collections and/or pancreatic necrosis. Mild AP was defined by exclusion. We compared this classification with AC in 144 episodes of AP. Results: In the three-category classification, severe AP was associated with significantly more frequent intensive care unit admission, invasive treatment and mortality than moderate and mild AP (p < 0.01). Severe AP patients required longer hospital stay and more nutritional support than mild AP patients (p < 0.01). Patients with moderate AP had significantly longer hospital stay and more need for nutritional support than patients with mild AP (p < 0.01). Five patients died, all of them with MOF and/or POF. Conclusions: A three-category classification distinguishes three homogeneous groups of severity.
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Presented in part at the 41st Meeting of the European Pancreatic Club in Szeged, Hungary, July 2009.
Received: November 24, 2009
Accepted after revision: March 13, 2010
Published online: October 30, 2010
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 6, Number of References : 30
Vol. 10, No. 5, Year 2010 (Cover Date: December 2010)
Journal Editor: Urrutia R. (Rochester, Minn.)
ISSN: 1424-3903 (Print), eISSN: 1424-3911 (Online)
For additional information: http://www.karger.com/PAN