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Vol. 5, No. 2, 2010
Issue release date: April 2010
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Breast Care 2010;5:66–73
(DOI:10.1159/000309138)
Review Article · Übersichtsarbeit

Epigenetic Signatures in Breast Cancer: Clinical Perspective

Parrella P.
Laboratorio di Oncologia, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy Breast Care 2010;5:66–73 (DOI:10.1159/000309138)

Abstract

There is now a compelling body of evidences sustaining the importance of epigenetic mechanisms in the development and progression of cancer. DNA methylation, post-translational histone and other protein modifications, microRNA expression, and nucleosome positioning, all act together to exert their cellular effects. The epigenome is responsible for controlling gene expression thus defining cell differentiation and tissue specificity. This review will focus on DNA methylation and histone modification because these epigenetic events are widely implicated in cancer development and progression. We will in particular address the translational aspects of breast cancer epigenomics including the development of biomarkers and the prospects for epigenetic based pharmacologic treatments. The analysis of DNA methylation has the advantage over other molecular methods (e.g. single gene mutation, microsatellite analysis) that it can be detected with a very high degree of specificity even in the presence of excess unmethylated DNA. Furthermore, the presence of specific CpG methylation signatures makes methylation-based markers attractive diagnostic, prognostic, and predictive tools for better management of breast cancer patients.

 goto top of outline Author Contacts

Dr. Paola Parrella, Oncology Laboratory, Viale Padre Pio, 71013 San Giovanni Rotondo (FG), Italy, Tel. +39 0882 41626-1, Fax -4, pparrella@operapadrepio.it


 goto top of outline Article Information

Published online: April 23, 2010
Number of Print Pages : 8


 goto top of outline Publication Details

Breast Care (Multidisciplinary Journal for Research, Diagnosis and Therapy)

Vol. 5, No. 2, Year 2010 (Cover Date: April 2010)

Journal Editor: Harbeck N. (Köln), Jakesz R. (Wien), Thomssen C. (Halle/Saale)
ISSN: 1661-3791 (Print), eISSN: 1661-3805 (Online)

For additional information: http://www.karger.com/BRC


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