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Vol. 76, No. 2, 1999
Issue release date: March 1999
Section title: Original Paper
Vox Sang 1999;76:120–123
(DOI:10.1159/000031031)

Pan–Reactive Platelet Antibodies in Post–Transfusion Purpura

Taaning E. · Tønnesen F.
aDepartment of Clinical Immunology, Glostrup Hospital, and bDepartments of Clinical Immunology and Oncology, Herlev Hospital, University of Copenhagen, Denmark

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 3/19/1999

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 0042-9007 (Print)
eISSN: 1423-0410 (Online)

For additional information: http://www.karger.com/VOX

Abstract

Background and Objectives: The mechanism for the destruction of a patient's own platelets in post–transfusion purpura (PTP) is unknown. In order to test the hypothesis that the destruction of autologous platelets in PTP is related to the presence of platelet antibodies with pan–reactivity, we investigated sera from patients with PTP. Materials and Methods: Sera from 12 patients with PTP were investigated for platelet antibodies by platelet–ELISA and monoclonal antibody–specific immobilization of platelet antigen assay. Results: During the thrombocytopenic phase, antibodies of IgG and IgM classes with pan–specificity against platelet GPIIb–IIIa, GPIb–IX and GPIa–IIa were found together with HPA alloantibodies. After recovery, the pan–specific antibodies disappeared or the extent of reactivity diminished, whereas the IgG HPA alloantibodies persisted. Conclusion: These findings provide evidence that transient panreactive antibodies may be responsible for the autologous platelet destruction in PTP.


  

Author Contacts

Ellen Taaning, MD, DSc
Department of Clinical Immunology and Bloodbank
Herlev Hospital
DK–2730 Herlev (Denmark)
Tel. +45 44 53 53 00, Fax +45 44 94 41 67

  

Article Information

Received: Received: July 8, 1997
Revised manuscript received: April 10, 1998
Accepted: August 5, 1998
Number of Print Pages : 4
Number of Figures : 1, Number of Tables : 1, Number of References : 11

  

Publication Details

Vox Sanguinis (International Journal of Transfusion Medicine)
Founded 1956 (formerly Bulletin of the Central Laboratory of the NRC Blood Transfusion Service, founded 1951)
Official Journal of the International Society of Blood Transfusion. Published in cooperation with the League of Red Cross Societies, Geneva

Vol. 76, No. 2, Year 1999 (Cover Date: Released March 1999)

Journal Editor: M. Contreras, London
ISSN: 0042–9007 (print), 1423–0410 (Online)

For additional information: http://www.karger.com/journals/vox


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 3/19/1999

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 0042-9007 (Print)
eISSN: 1423-0410 (Online)

For additional information: http://www.karger.com/VOX


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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