Background and Objectives: The mechanism for the destruction of a patient's own platelets in post–transfusion purpura (PTP) is unknown. In order to test the hypothesis that the destruction of autologous platelets in PTP is related to the presence of platelet antibodies with pan–reactivity, we investigated sera from patients with PTP. Materials and Methods: Sera from 12 patients with PTP were investigated for platelet antibodies by platelet–ELISA and monoclonal antibody–specific immobilization of platelet antigen assay. Results: During the thrombocytopenic phase, antibodies of IgG and IgM classes with pan–specificity against platelet GPIIb–IIIa, GPIb–IX and GPIa–IIa were found together with HPA alloantibodies. After recovery, the pan–specific antibodies disappeared or the extent of reactivity diminished, whereas the IgG HPA alloantibodies persisted. Conclusion: These findings provide evidence that transient panreactive antibodies may be responsible for the autologous platelet destruction in PTP.
Ellen Taaning, MD, DSc
Department of Clinical Immunology and Bloodbank
DK–2730 Herlev (Denmark)
Tel. +45 44 53 53 00, Fax +45 44 94 41 67
Received: Received: July 8, 1997
Revised manuscript received: April 10, 1998
Accepted: August 5, 1998
Number of Print Pages : 4
Number of Figures : 1, Number of Tables : 1, Number of References : 11
Vox Sanguinis (International Journal of Transfusion Medicine)
Founded 1956 (formerly Bulletin of the Central Laboratory of the NRC Blood Transfusion Service, founded 1951)
Official Journal of the International Society of Blood Transfusion. Published in cooperation with the League of Red Cross Societies, Geneva
Vol. 76, No. 2, Year 1999 (Cover Date: Released March 1999)
Journal Editor: M. Contreras, London
ISSN: 0042–9007 (print), 1423–0410 (Online)
For additional information: http://www.karger.com/journals/vox
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