Phosphatidylserine Containing ω–3 Fatty Acids May Improve Memory Abilities in Non-Demented Elderly with Memory Complaints: A Double-Blind Placebo-Controlled TrialVakhapova V.a · Cohen T.c · Richter Y.c · Herzog Y.c · Korczyn A.D.b
aNeurology Department, Tel-Aviv Sourasky Medical Center, and bSieratzki Chair of Neurology, Tel-Aviv University Medical School, Tel-Aviv, and cEnzymotec Ltd., Migdal HaEmeq, Israel
Background: Phosphatidylserine (PS) may have beneficial effects on cognitive functions. We evaluated the efficacy of a novel preparation of PS containing ω–3 long-chain polyunsaturated fatty acids attached to its backbone (PS-DHA) in non-demented elderly with memory complaints. Methods: 157 participants were randomized to receive either PS-DHA or placebo for 15 weeks. Efficacy measures, assessed at baseline and endpoint, included the Rey Auditory Verbal Learning Test, Rey Complex Figure Test, and a computerized cognitive battery. Clinicians’ Global Impression of Change was assessed following 7 and 15 weeks of treatment. Results: 131 participants completed the study although 9 were excluded from the efficacy analysis due to protocol violation. At endpoint, verbal immediate recall was significantly improved in the PS-DHA group compared to the placebo group. Post-hoc analysis revealed that a subset of participants with relatively good cognitive performance at baseline had significant treatment-associated improvements in immediate and delayed verbal recall, learning abilities, and time to copy complex figure. These favorable results were further supported by responder analysis. Conclusions: The results indicate that PS-DHA may improve cognitive performance in non-demented elderly with memory complaints. Post-hoc analysis of subgroups suggests that participants with higher baseline cognitive status were most likely to respond to PS-DHA. The results of this exploratory study should be followed up by additional studies aimed at confirming the present tentative conclusions.
© 2010 S. Karger AG, Basel
This study was funded by Enzymotec Ltd., Israel. T.C., Y.R., and Y.H. are employees of Enzymotec, and A.D.K. served as consultant to the study.
Accepted: March 25, 2010
Published online: June 3, 2010
Number of Print Pages : 8
Number of Figures : 1, Number of Tables : 4, Number of References : 37
Dementia and Geriatric Cognitive Disorders
Vol. 29, No. 5, Year 2010 (Cover Date: June 2010)
Journal Editor: Chan-Palay V. (New York, N.Y.)
ISSN: 1420-8008 (Print), eISSN: 1421-9824 (Online)
For additional information: http://www.karger.com/DEM