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Vol. 29, No. 5, 2010
Issue release date: June 2010
Section title: Original Research Article
Dement Geriatr Cogn Disord 2010;29:467–474
(DOI:10.1159/000310330)

Phosphatidylserine Containing ω–3 Fatty Acids May Improve Memory Abilities in Non-Demented Elderly with Memory Complaints: A Double-Blind Placebo-Controlled Trial

Vakhapova V. · Cohen T. · Richter Y. · Herzog Y. · Korczyn A.D.
aNeurology Department, Tel-Aviv Sourasky Medical Center, and bSieratzki Chair of Neurology, Tel-Aviv University Medical School, Tel-Aviv, and cEnzymotec Ltd., Migdal HaEmeq, Israel

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 3/25/2010
Published online: 6/3/2010

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 4

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Background: Phosphatidylserine (PS) may have beneficial effects on cognitive functions. We evaluated the efficacy of a novel preparation of PS containing ω–3 long-chain polyunsaturated fatty acids attached to its backbone (PS-DHA) in non-demented elderly with memory complaints. Methods: 157 participants were randomized to receive either PS-DHA or placebo for 15 weeks. Efficacy measures, assessed at baseline and endpoint, included the Rey Auditory Verbal Learning Test, Rey Complex Figure Test, and a computerized cognitive battery. Clinicians’ Global Impression of Change was assessed following 7 and 15 weeks of treatment. Results: 131 participants completed the study although 9 were excluded from the efficacy analysis due to protocol violation. At endpoint, verbal immediate recall was significantly improved in the PS-DHA group compared to the placebo group. Post-hoc analysis revealed that a subset of participants with relatively good cognitive performance at baseline had significant treatment-associated improvements in immediate and delayed verbal recall, learning abilities, and time to copy complex figure. These favorable results were further supported by responder analysis. Conclusions: The results indicate that PS-DHA may improve cognitive performance in non-demented elderly with memory complaints. Post-hoc analysis of subgroups suggests that participants with higher baseline cognitive status were most likely to respond to PS-DHA. The results of this exploratory study should be followed up by additional studies aimed at confirming the present tentative conclusions.


  

Author Contacts

Prof. Amos D. Korczyn
Sieratzki Chair of Neurology
Tel-Aviv University Medical School
IL–69978 Ramat Aviv (Israel)
Tel. +972 3 697 4229, Fax +972 3 640 9113, E-Mail amoskor@post.tau.ac.il

  

Article Information

This study was funded by Enzymotec Ltd., Israel. T.C., Y.R., and Y.H. are employees of Enzymotec, and A.D.K. served as consultant to the study.

Accepted: March 25, 2010
Published online: June 3, 2010
Number of Print Pages : 8
Number of Figures : 1, Number of Tables : 4, Number of References : 37

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 29, No. 5, Year 2010 (Cover Date: June 2010)

Journal Editor: Chan-Palay V. (New York, N.Y.)
ISSN: 1420-8008 (Print), eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 3/25/2010
Published online: 6/3/2010

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 4

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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