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Table of Contents
Vol. 115, No. 2, 2010
Issue release date: June 2010
Section title: Original Paper
Nephron Clin Pract 2010;115:c154–c160
(DOI:10.1159/000312879)

Predicting Cisplatin-Induced Acute Kidney Injury by Urinary Neutrophil Gelatinase-Associated Lipocalin Excretion: A Pilot Prospective Case-Control Study

Gaspari F.a · Cravedi P.a · Mandalà M.b · Perico N.a · de Leon F.R.a · Stucchi N.a · Ferrari S.a · Labianca R.b · Remuzzi G.a · Ruggenenti P.a
aDepartment of Medicine and Transplantation, Ospedali Riuniti, Mario Negri Institute for Pharmacological Research, and bUnità Operativa Oncologia Medica, Ospedali Riuniti, Bergamo, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 28, 2009
Accepted: October 26, 2009
Published online: April 21, 2010
Issue release date: June 2010

Number of Print Pages: 1
Number of Figures: 2
Number of Tables: 1

ISSN: (Print)
eISSN: 1660-2110 (Online)

For additional information: http://www.karger.com/NEC

Abstract

Background/Aims: Nephrotoxicity is the major limitation to cisplatin therapy for solid tumors. We aimed at evaluating whether early increases in serum/urine levels of neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of tubular damage and regeneration, predict cisplatin-induced acute kidney injury (AKI). Methods: We compared changes in serum creatinine and serum/urine NGAL levels (ELISA assay) at 1 and 4 h and 1, 2, 3, 7 and 15 days after cisplatin infusion (70–80 mg/m2) versus baseline in 12 consecutive cancer patients (cases) with AKI (>25% serum creatinine increase vs. baseline) and 12 consecutive controls without AKI. Results: Baseline characteristics and posttreatment serum NGAL levels were similar in both groups. Urinary NGAL levels increased significantly more in cases than in controls at 1, 2, 3 and 15 days after cisplatin. The NGAL increase preceded AKI by 4.5 days and the NGAL increase at day 2 after cisplatin independently predicted AKI (p < 0.05). Six cases with residual kidney dysfunction at 15 days showed a trend to earlier and higher increase in urinary NGAL levels compared to cases with renal function recovery. Conclusion: An early increase in urinary NGAL excretion may help in identifying patients at risk of cisplatin-induced AKI who might benefit from innovative treatments to prevent cisplatin nephrotoxicity.

© 2010 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 28, 2009
Accepted: October 26, 2009
Published online: April 21, 2010
Issue release date: June 2010

Number of Print Pages: 1
Number of Figures: 2
Number of Tables: 1

ISSN: (Print)
eISSN: 1660-2110 (Online)

For additional information: http://www.karger.com/NEC


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