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Vol. 23, No. 6, 2010
Issue release date: September 2010
Section title: Original Paper
Skin Pharmacol Physiol 2010;23:290–297
(DOI:10.1159/000313516)

Effect of Topical Application of Virgin Coconut Oil on Skin Components and Antioxidant Status during Dermal Wound Healing in Young Rats

Nevin K.G. · Rajamohan T.
Department of Biochemistry, University of Kerala, Thiruvananthapuram, India

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/26/2009
Accepted: 3/25/2010
Published online: 6/3/2010

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 2

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

Objectives: The present study was undertaken to evaluate the effect of a topical application of virgin coconut oil (VCO) on excision wounds in young rats. Methods: Three sets of experiments with 3 groups of female Sprague-Dawley rats each consisting of 6 animals were used for studying wound closure time, antioxidant status and biochemical parameters. Group 1 was the control; groups 2 and 3 were treated with 0.5 and 1.0 ml VCO, respectively, 24 h after wound creation for 10 days. After the experimental period, the healing property of VCO was evaluated by monitoring the time taken for complete epithelization as well as levels of various parameters of the wound’s granulation tissue. The collagen solubility pattern, glycohydrolase activity, and histopathology of the granulation tissue were also analyzed. The antioxidant status during wound healing was monitored continuously for 14 days. Results: VCO-treated wounds healed much faster, as indicated by a decreased time of complete epithelization and higher levels of various skin components. Pepsin-soluble collagen showed a significant increase in VCO- treated wounds, indicating a higher collagen cross-linking. Glycohydrolase activities were also found to be increased due to a higher turnover of collagen. Antioxidant enzyme activities, and reduced glutathione and malondialdehyde levels were found to be increased on the 10th day after wounding, which were found to have returned to normal levels on day 14 in the treated wounds. The lipid peroxide levels were found to be lower in the treated wounds. A histopathological study showed an increase in fibroblast proliferation and neovascularization in VCO-treated wounds compared to controls. Conclusion: The beneficial effect of VCO can be attributed to the cumulative effect of various biologically active minor components present in it.


  

Author Contacts

Dr. T. Rajamohan
Department of Biochemistry
University of Kerala, Kariavattom
Thiruvananthapuram, Kerala 695581 (India)
Tel. +91 471 241 8078, Fax +91 471 230 7158, E-Mail trmohan2003@rediffmail.com

  

Article Information

Received: October 26, 2009
Accepted after revision: March 25, 2010
Published online: June 3, 2010
Number of Print Pages : 8
Number of Figures : 3, Number of Tables : 2, Number of References : 58

  

Publication Details

Skin Pharmacology and Physiology (Journal of Pharmacological and Biophysical Research)

Vol. 23, No. 6, Year 2010 (Cover Date: September 2010)

Journal Editor: Lademann J. (Berlin)
ISSN: 1660-5527 (Print), eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/26/2009
Accepted: 3/25/2010
Published online: 6/3/2010

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 2

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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