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Table of Contents
Vol. 30, No. 1, 2010
Issue release date: June 2010
Section title: Original Paper
Cerebrovasc Dis 2010;30:36–40
(DOI:10.1159/000313608)

Migraine with Aura Is a Risk Factor for Cervical Artery Dissection: A Case-Control Study

Artto V.a · Metso T.M.a · Metso A.J.a · Putaala J.a · Haapaniemi E.a · Wessman M.b, c · Färkkilä M.a · Kallela M.a · Tatlisumak T.a
aDepartment of Neurology, Helsinki University Central Hospital, bBiomedicum Helsinki, Research Program in Molecular Medicine, University of Helsinki, and cFolkhälsan Research Center, Helsinki, Finland

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 12, 2009
Accepted: January 29, 2010
Published online: April 29, 2010
Issue release date: June 2010

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Background: Cervical artery dissection (CAD) is the most common single etiology for stroke in young adults. Migraine, especially with aura (MA), is a known risk factor for ischemic stroke. The association between CAD and migraine was suggested based on a few small studies, but there are no large-scale case-control data, and the mechanisms are not yet clear. Methods: We compared the lifetime prevalence of migraine and migraine characteristics in 313 CAD patients with 313 healthy age- and sex-matched controls. We also analyzed clinical and radiological characteristics of CAD with respect to migraine subtypes to investigate whether clear phenotypical associations can be found that might help in the search for a possible shared genetic background for migraine and CAD. Results: Migraine was clearly more common in CAD patients than in controls (36 vs. 23%; OR 2.15; 95% CI 1.48–3.14), and the association was also highly significant for MA (23 vs. 12%; OR 2.41; 95% CI 1.53–3.80). Percentages of reported migraine history and MA of CAD patients vs. controls compared separately for both sexes were as follows: for women, migraine 54 vs. 35% (OR 2.30; 95% CI 1.28–4.13), MA 35 vs. 18% (OR 2.79; 95% CI 1.40–5.59); for men, migraine 27 vs. 16% (OR 2.02; 95% CI 1.23–3.31), MA 16 vs. 10% (OR 2.21; 95% CI 1.19–4.11). Over 60% of the CAD patients with still active migraine at the time of dissection reported later alleviation of migraine activity. Conclusion: Our observations suggest that patients with CAD are a significant link between ischemic stroke and migraine. This connection may represent a common pathophysiological or genetic background, or both. Migraine activity appears to be alleviated by CAD.

© 2010 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 12, 2009
Accepted: January 29, 2010
Published online: April 29, 2010
Issue release date: June 2010

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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