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Vol. 32, No. 1, 2010
Issue release date: July 2010
Section title: Original Report: Transplantation
Am J Nephrol 2010;32:1–9
(DOI:10.1159/000313940)

Different Immunosuppressive Combinations on T-Cell Regulation in Renal Transplant Recipients

Fourtounas C. · Dousdampanis P. · Sakellaraki P. · Rodi M. · Georgakopoulos T. · Vlachojannis J.G. · Mouzaki A.
Department of Internal Medicine, Divisions of aNephrology and bHematology, Medical School and University Hospital, Patras, Greece

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Article / Publication Details

First-Page Preview
Abstract of Original Report: Transplantation

Received: 3/29/2010
Accepted: 4/14/2010
Published online: 5/20/2010

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 3

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN

Abstract

Background/Aims: Recent studies indicate that regulatory T-cells (Tregs) promote transplant tolerance. We studied Treg levels in 39 stable renal transplant recipients to determine the sizes of the Treg populations and the effects of treatment regimens thereof. Methods: All patients (19 with good graft function and 20 with chronic allograft nephropathy) received induction therapy (basiliximab) and were on triple immunosuppressive regimens with calcineurin inhibitors (cyclosporine or tacrolimus), mycophenolate mofetil (MMF) or everolimus and steroids. Twenty healthy subjects served as controls. Whole blood samples were stained with anti-CD4, CD25, CD127, and FoxP3 antibodies and analyzed by flow cytometry to determine CD4+CD25highFoxP3± and CD4+ CD25highCD127–/low Treg levels. Results:All patients had significantly reduced CD4+CD25highFoxP3± but no CD4+ CD25highCD127–/low Treg levels compared to controls. Renal allograft function did not correlate with Treg levels. Statistically significant correlations between CD4+CD25highFoxp3+ Tregs and tacrolimus levels and CD4+CD25highFoxp3– Tregs and HLA-DR mismatching were detected. Patients receiving MMF had significantly higher CD4+CD25highFoxp3+ Tregs compared to patients on everolimus who were also receiving lower doses of calcineurin inhibitors. Conclusion:Overall, immunosuppression lowers CD4+CD25highFoxP3± Treg levels significantly in the periphery in renal transplant recipients. In addition, different immunosuppressive regimens have different impacts on CD4+CD25highFoxP3+ Tregs, a fact that may influence long-term allograft survival.


  

Author Contacts

Athanasia Mouzaki
Division of Hematology, Department of Internal Medicine, Medical School
University of Patras
GR–26500 Rion, Patras (Greece)
Tel./Fax +30 261 096 9123, E-Mail mouzaki@med.upatras.gr

  

Article Information

Received: March 29, 2010
Accepted: April 14, 2010
Published online: May 20, 2010
Number of Print Pages : 9
Number of Figures : 3, Number of Tables : 3, Number of References : 29

  

Publication Details

American Journal of Nephrology

Vol. 32, No. 1, Year 2010 (Cover Date: July 2010)

Journal Editor: Bakris G. (Chicago, Ill.)
ISSN: 0250-8095 (Print), eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN


Article / Publication Details

First-Page Preview
Abstract of Original Report: Transplantation

Received: 3/29/2010
Accepted: 4/14/2010
Published online: 5/20/2010

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 3

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN


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