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Table of Contents
Vol. 221, No. 2, 2010
Issue release date: August 2010
Section title: Case and Review
Dermatology 2010;221:97–106
(DOI:10.1159/000314160)

Two Congenital Cases of Pigmented Epithelioid Melanocytoma Studied by Fluorescent in situ Hybridization for Melanocytic Tumors: Case Reports and Review of These Recent Topics

Battistella M.a · Prochazkova-Carlotti M.e · Berrebi D.c · Bennaceur S.d · Edan C.f · Riffaud L.g · Rütten A.h · Fraitag S.b
aDermatology and bPathology, Necker-Enfants Malades Hospital, APHP, Paris V – Descartes University, and cPathology and dPlastic Surgery, Robert-Debré Hospital, APHP, Paris, eHistology and Molecular Pathology of Tumours, EA 2406, Victor Segalen Bordeaux 2 University, Bordeaux, and fDepartment of Pediatrics and gNeurosurgery, Rennes University Hospital, Rennes, France; hDermatopathologische Gemeinschaftspraxis, Friedrichshafen, Germany

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Article / Publication Details

First-Page Preview
Abstract of Case and Review

Received: December 04, 2009
Accepted: April 20, 2010
Published online: June 18, 2010
Issue release date: August 2010

Number of Print Pages: 10
Number of Figures: 5
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

The term ‘pigmented epithelioid melanocytoma’ (PEM) has recently been proposed as a nosological framework grouping lesions formerly known as animal-type melanomas, sporadic epithelioid blue nevi and Carney complex-associated epithelioid blue nevi. Congenital PEMs have been reported extremely rarely and their prognosis is poorly known. Four-color fluorescent in situ hybridization (FISH) for melanocytic lesions is a recent method developed to assess the malignant potential of ambiguous melanocytic lesions. Here we describe 2 cases of congenital epithelioid and strongly pigmented melanocytic lesions consistent with PEM. No BRAF gene mutation was found in the 2 cases. FISH for melanocytic lesions was also performed. The first case proved entirely negative, whereas the second one showed a positive zone with an extra copy of chromosome 6. The prognosis and management of PEM are discussed, with a review of the available data on the history, demographics, molecular alterations and histopathological aspects of this entity. PEM seems to represent a unique low-grade melanocytic tumor with a limited potential of metastasis to lymph nodes, but a favorable long-term clinical course. The published data about FISH for melanocytic tumors, and especially PEM, are reviewed. Four-color FISH may be a useful tool to assess more accurately the prognosis of these tumors.

© 2010 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Case and Review

Received: December 04, 2009
Accepted: April 20, 2010
Published online: June 18, 2010
Issue release date: August 2010

Number of Print Pages: 10
Number of Figures: 5
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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