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Table of Contents
Vol. 62, No. 1, 2010
Issue release date: June 2010
Section title: Paper
Neuropsychobiology 2010;62:43–49
(DOI:10.1159/000314309)

Lithium Reduces Pathological Aggression and Suicidality: A Mini-Review

Müller-Oerlinghausen B.a · Lewitzka U.b
aDrug Commission of the German Medical Association, Berlin, and bDepartment of Psychiatry and Psychotherapy, Technical University of Dresden, Dresden, Germany

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: May 07, 2010
Issue release date: June 2010

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

From a practical point of view, the well-proven antisuicidal and anti-aggressive effects of lithium are of utmost importance for a rational, safe and economical treatment of patients with affective disorders. Regular lithium long-term treatment reduces the otherwise 2- to 3-fold increased mortality of untreated patients with severe affective disorders down to the level of the general population. This is mainly due to the reduced suicide risk. Many international studies have confirmed this fascinating property of lithium which so far has not been demonstrated with comparable evidence for any other psychotropic compound. The antisuicidal effects of lithium might possibly be related to its anti-aggressive effects which have been shown in various species, populations and settings, such as animals, inhabitants of nursing homes for the elderly, mentally handicapped subjects, children and adolescents with hyperactive, hostile and aggressive behavior, and particularly in hyperaggressive inmates of correction units and prisons.

© 2010 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: May 07, 2010
Issue release date: June 2010

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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