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The International Consortium on Lithium Genetics (ConLiGen): An Initiative by the NIMH and IGSLI to Study the Genetic Basis of Response to Lithium TreatmentSchulze T.G.a, g,ε · Alda M.m, ε · Adli M.h, ε · Akula N.a · Ardau R.t · Bui E.T.a · Chillotti C.t · Cichon S.i, ζ · Czerski P.v · Del Zompo M.t, u · Detera-Wadleigh S.D.a · Grof P.n, o, ε · Gruber O.j · Hashimoto R.x, δ · Hauser J.v · Hoban R.b, c · Iwata N.y, δ · Kassem L.a · Kato T.z, δ · Kittel-Schneider S.k · Kliwicki S.w · Kelsoe J.R.b, c · Kusumi I.β, δ · Laje G.a · Leckband S.G.b, d, e · Manchia M.u · MacQueen G.p · Masui T.β, δ · Ozaki N.γ, δ · Perlis R.H.f · Pfennig A.l, ε · Piccardi P.u · Richardson S.a · Rouleau G.q · Reif A.k · Rybakowski J.K.w, ε · Sasse J.l, ε · Schumacher J.a, i · Severino G.u · Smoller J.W.f · Squassina A.u · Turecki G.r · Young L.T.s, ε · Yoshikawa T.α, δ · Bauer M.l, ε · McMahon F.J.a
aGenetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Md., bDepartment of Psychiatry, University of California San Diego, cDepartment of Psychiatry, VA San Diego Healthcare System, and dDepartment of Pharmacy, VA San Diego Healthcare System, La Jolla, Calif., eSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, Calif., and fDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Mass., USA; gDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, hDepartment of Psychiatry and Psychotherapy, Charité – Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, iDepartment of Genomics, Life and Brain Center and Institute of Human Genetics, University of Bonn, Bonn, jDepartment of Psychiatry and Psychotherapy, Georg-August University, Göttingen, kDepartment of Psychiatry, Psychosomatics, and Psychotherapy, University of Würzburg, Würzburg, and lDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; mDepartment of Psychiatry, Dalhousie University, Halifax, N.S., nMood Disorders Center of Ottawa, Ottawa, Ont., oDepartment of Psychiatry, University of Toronto, Toronto, Ont., pDepartment of Psychiatry, University of Calgary, Calgary, Alta., qCHU Sainte-Justine Research Center, Department of Medicine, University of Montreal, and rDepartment of Psychiatry, Douglas Hospital Research Institute, McGill University, Montreal, Que., and sDepartment of Psychiatry, University of British Columbia, Vancouver, B.C., Canada; tUnit of Clinical Pharmacology, Hospital University Agency, and uDepartment of Neuroscience ‘B.B. Brodie’, University of Cagliari, Cagliari, Italy; vPsychiatric Genetic Unit, and wDepartment of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland; wOsaka University Graduate School of Medicine, Osaka,yDepartment of Psychiatry, Fujita Health University School of Medicine, Toyoake,zLaboratory for Molecular Dynamics of Mental Disorders, andαLaboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama,βDepartment of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo,γDepartment of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan;δThe Japanese Collaborative Group on the Genetics of Lithium Response in Bipolar Disorder;εThe International Group for the Study of Lithium-Treated Patients (IGSLI);ζInstitute of Neurosciences and Medicine (INM-1), Research Center Juelich, Juelich, Germany Corresponding Author
Thomas G. Schulze, MD, Unit on the Genetic Basis of Mood and Anxiety Disorders
National Institute of Mental Health (NIMH), National Institutes of Health (NIH)
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For more than half a decade, lithium has been successfully used to treat bipolar disorder. Worldwide, it is considered the first-line mood stabilizer. Apart from its proven antimanic and prophylactic effects, considerable evidence also suggests an antisuicidal effect in affective disorders. Lithium is also effectively used to augment antidepressant drugs in the treatment of refractory major depressive episodes and prevent relapses in recurrent unipolar depression. In contrast to many psychiatric drugs, lithium has outlasted various pharmacotherapeutic ‘fashions’, and remains an indispensable element in contemporary psychopharmacology. Nevertheless, data from pharmacogenetic studies of lithium are comparatively sparse, and these studies are generally characterized by small sample sizes and varying definitions of response. Here, we present an international effort to elucidate the genetic underpinnings of lithium response in bipolar disorder. Following an initiative by the International Group for the Study of Lithium-Treated Patients (www.IGSLI.org) and the Unit on the Genetic Basis of Mood and Anxiety Disorders at the National Institute of Mental Health,lithium researchers from around the world have formed the Consortium on Lithium Genetics (www.ConLiGen.org) to establish the largest sample to date for genome-wide studies of lithium response in bipolar disorder, currently comprising more than 1,200 patients characterized for response to lithium treatment. A stringent phenotype definition of response is one of the hallmarks of this collaboration. ConLiGen invites all lithium researchers to join its efforts.
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