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Vol. 124, No. 1, 2010
Issue release date: July 2010
Section title: Case Report
Acta Haematol 2010;124:5–8
(DOI:10.1159/000314900)

T Cell Large Granular Lymphocytic Leukemia in Association with Sjögren’s Syndrome

Franco G. · Palazzolo R. · Liardo E. · Tripodo C. · Mancuso S.
aDivision of Hematology with BMT, Department of Oncology, and bDepartment of Human Pathology, University of Palermo, Palermo, Italy

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Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: 11/16/2009
Accepted: 3/17/2010
Published online: 5/26/2010

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

T cell large granular lymphocytic (LGL) leukemia is a rare condition accounting for 2–3% of all mature lymphoid leukemias. Here, we present the case of a 73-year-old woman presenting with neutropenia and anemia (hemoglobin 9.9 g/dl). Hematological assessment revealed the presence of a T cell LGL leukemia. At the time of T cell LGL leukemia diagnosis, the patient developed xerophthalmia and xerostomia, and a diagnosis of Sjögren’s syndrome was made following salivary gland biopsy. The finding of large granular lymphocytes in the context of autoimmune disorders is well-known, though it often occurs with rheumatoid arthritis or in association with a positive autoantibody titer in the absence of an overt clinical picture. The concomitant presentation of T cell LGL leukemia with Sjögren’s syndrome is a rare event which is worth reporting. Our patient was managed with immunosuppressive therapy and is still alive.


  

Author Contacts

Giovanni Franco, MD
Department of Oncology, Division of Hematology with BMT
University of Palermo, via del Vespro 129
IT–90127 Palermo (Italy)
Tel. +39 091 655 4405, Fax +39 091 655 4423, E-Mail giovifranco@gmail.com

  

Article Information

Received: November 16, 2009
Accepted after revision: March 17, 2010
Published online: May 26, 2010
Number of Print Pages : 4
Number of Figures : 2, Number of Tables : 0, Number of References : 13

  

Publication Details

Acta Haematologica

Vol. 124, No. 1, Year 2010 (Cover Date: July 2010)

Journal Editor: Ben-Bassat I. (Qiryat-Ono)
ISSN: 0001-5792 (Print), eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: 11/16/2009
Accepted: 3/17/2010
Published online: 5/26/2010

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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