Effects of Different Varieties of Maca (Lepidium meyenii) on Bone Structure in Ovariectomized RatsGonzales C. · Cárdenas-Valencia I. · Leiva-Revilla J. · Anza-Ramirez C. · Rubio J. · Gonzales G.F.
a Biological and Physiological Science Department, Faculty of Science and Philosophy, Universidad Peruana Cayetano Heredia, b Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Lima, Peru
Objective: This study was designed to determine the effect of different varieties of maca (Lepidium meyenii) on bone structure in ovariectomized (OVX) rats. Materials and Methods: 36 female rats were randomly divided into 6 groups: sham and OVX rats treated with vehicle, estradiol (40 μg/kg), black, yellow or red maca (63 mg/ml) for 4 weeks. At the end of the treatment, uterine weight, femoral bone and lumbar vertebra histomorphology were assessed. Results: Ovariectomy reduced weight, diameter and width of the femoral bone. Estradiol, black and red maca treatment reduced the effect of ovariectomy on these variables. Histological analyses revealed that estradiol, black and red maca treatments reversed the effect of ovariectomy by increasing the trabecular bone area in the second lumbar vertebra. Uterine weight was reduced in OVX rats, and estradiol but neither black nor red maca increased uterine weight. Conclusion: Red and black maca have protective effects on bone architecture in OVX rats without showing estrogenic effects on uterine weight.
Carla Gonzales, Biological and Physiological Science Department, Faculty of Science and Philosophy, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, Lima 31, Peru, Tel. +511 3190000, ext. 2515, firstname.lastname@example.org
Published online: June 16, 2010
Number of Print Pages : 7
Forschende Komplementärmedizin / Research in Complementary Medicine (Research Practice Perspectives - Wissenschaft Praxis Perspektiven)
Vol. 17, No. 3, Year 2010 (Cover Date: June 2010)
Journal Editor: Walach H. (Frankfurt/O.)
ISSN: 1661-4119 (Print), eISSN: 1661-4127 (Online)
For additional information: http://www.karger.com/FOK