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Vol. 78, Suppl. 1, 2010
Issue release date: July 2010
Section title: Paper
Oncology 2010;78(suppl 1):17–23
(DOI:10.1159/000315225)

Interferon Reduces the Risk of Hepatocellular Carcinoma in Hepatitis C Virus-Related Chronic Hepatitis/Liver Cirrhosis

Masuzaki R. · Yoshida H. · Omata M.
Department of Gastroenterology, University of Tokyo, Tokyo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 7/8/2010

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 5

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

The efficacy of interferon therapy against hepatitis C virus (HCV) has much improved, showing a sustained virologic response rate of 40–50% even in the genotype 1b with a high viral load. Several cohort studies conducted in Japan in the 1990s unanimously concluded that the risk of hepatocellular carcinoma (HCC) development was reduced in patients who achieved a sustained virologic response or persistent normalization of alanine aminotransferase as compared to untreated patients. Recently, a large-scale randomized controlled trial, called the HALT-C study, showed no significant difference in the incidence of HCC between patients on maintenance interferon therapy and those without. The reason for the discrepant results in Japanese and USA studies needs further clarification, together with analysis of the difference in incidence rates of HCC among cirrhotic patients. There has also been progress in the treatment of HCC, and together with advances in diagnostics facilitating HCC detection at an early stage, tumor nodules can often be completely removed either by medical ablation or surgical resection. Nevertheless, recurrence of HCC after apparently curative treatment is extraordinarily frequent, since the remaining liver is still at a high risk of HCC. The prevention of the recurrence of HCC, or tertiary prevention, is currently one of the most challenging tasks in hepatology.


  

Author Contacts

Prof. Masao Omata
University of Tokyo
7-3-1 Hongo, Bunkyo-ku
Tokyo 113-8655 (Japan)
Tel. +81 3 3815 5411, Fax +81 3 3814 0021, E-Mail momata-tky@umin.ac.jp

  

Article Information

Published online: July 8, 2010
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 5, Number of References : 30

  

Publication Details

Oncology (International Journal of Cancer Research and Treatment)

Vol. 78, No. Suppl. 1, Year 2010 (Cover Date: July 2010)

Journal Editor: Markman M. (Houston, Tex.)
ISSN: 0030-2414 (Print), eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 7/8/2010

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 5

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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