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Vol. 221, Suppl. 1, 2010
Issue release date: August 2010
Section title: Paper
Dermatology 2010;221(suppl 1):29–42
(DOI:10.1159/000316179)

Treatment and Management of Psoriasis with Nail Involvement: A Focus on Biologic Therapy

Langley R.G.a · Daudén E.b
aDalhousie University, Halifax, N.S., Canada; bHospital Universitario de la Princesa, Madrid, Spain

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 8/9/2010
Issue release date: August 2010

Number of Print Pages: 14
Number of Figures: 1
Number of Tables: 6

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Nail involvement in psoriasis is typically overlooked, although it can affect up to 50% of patients with psoriasis and cause functional impact as well as psychological stress that can significantly affect quality of life. In addition, psoriatic patients with nail disease tend to have a more severe skin condition, a higher rate of unremitting and progressive arthritis and more associated anxiety and depression. Historically, the treatment of nail psoriasis has proven difficult, with most patients feeling that the treatment for their nail disease was unsatisfactory. The current management of nail psoriasis includes topical, intralesional and systemic therapies, although little clinical evidence is available on the effectiveness of conventional treatments and, consequently, no specific treatment approach has been fully supported. Biologic agents are beginning to emerge as a viable option to treat patients with both cutaneous and nail clinical manifestations of psoriasis and psoriatic arthritis. The extra disease burden that nail symptoms place on the patient can be considered indicative of a more severe form of the disease and should be taken into consideration when assessing treatment options.

© 2010 S. Karger AG, Basel


  

Author Contacts

Richard Langley, MD
4195 Dickson Building, Queen Elizabeth II Health Sciences Centre
Dalhousie University, 1278 University Avenue
Halifax, NS B3H 2Y9 (Canada)
Tel. +1 902 425 8038, Fax +1 902 431 8882, E-Mail richard.langley@dal.ca

  

Article Information

Published online: August 9, 2010
Number of Print Pages : 14
Number of Figures : 1, Number of Tables : 6, Number of References : 75

  

Publication Details

Dermatology

Vol. 221, No. Suppl. 1, Year 2010 (Cover Date: August 2010)

Journal Editor: Saurat J.-H. (Geneva)
ISSN: 1018-8665 (Print), eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 8/9/2010
Issue release date: August 2010

Number of Print Pages: 14
Number of Figures: 1
Number of Tables: 6

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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