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Table of Contents
Vol. 153, No. 4, 2010
Issue release date: November 2010
Section title: Original Paper
Int Arch Allergy Immunol 2010;153:419–423
(DOI:10.1159/000316354)

HLA Status in Patients with Chronic Spontaneous Urticaria

Bozek A.a · Krajewska J.b · Filipowska B.a · Polanska J.c · Rachowska R.a · Grzanka A.a · Jarzab J.a
aClinical Department of Internal Medicine, Dermatology and Allergology, Medical University of Silesia, Zabrze, and bDepartment of Nuclear Medicine and Endocrine Oncology, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, and cSilesian University of Technology, Faculty of Automatic Control, Electronics and Computer Science, Gliwice, Poland

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 21, 2008
Accepted: February 01, 2010
Published online: June 18, 2010
Issue release date: November 2010

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Chronic spontaneous urticaria (CSU) is the most common form of chronic urticaria. A considerable amount of data supports an immunological basis for CSU. Some research has focused on the association between chronic urticaria and specific human leukocyte antigen (HLA) alleles. The aim of this study was to investigate the HLA status of Polish patients diagnosed with CSU. Methods: The standard complement-dependent microlymphocytotoxicity assay and PCR amplification with sequence-specific primers were used to analyze HLA alleles in 115 patients diagnosed with CSU, and the results were compared to those from 162 healthy, genetically unrelated individuals. Results: Among the HLA-A alleles, A-33 occurred significantly more often in the control group (p < 0.01). Analysis of the HLA-B allele frequencies revealed the prevalence of the B44 antigen in the study group (p < 0.0001). Frequencies of HLA-C alleles and HLA-DQ did not differ significantly between the groups. Among the HLA class II alleles, DRB1*04 was observed significantly more often in the study population (p < 0.001), mainly in the autoimmunological subtype of urticaria. Conclusion: HLA alleles may be involved in CSU development or play a protective role in CSU.

© 2010 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 21, 2008
Accepted: February 01, 2010
Published online: June 18, 2010
Issue release date: November 2010

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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