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Cover

Adipose Tissue Development

From Animal Models to Clinical Conditions
3rd ESPE Advanced Seminar in Developmental Endocrinology, Paris, March 2009

Editor(s): Levy-Marchal C. (Paris) 
Pénicaud L. (Dijon) 
Table of Contents
Vol. 19, No. , 2010
Section title: Paper
Levy-Marchal C, Pénicaud L (eds): Adipose Tissue Development: From Animal Models to Clinical Conditions. Endocr Dev. Basel, Karger, 2010, vol 19, pp 45–52
(DOI:10.1159/000316896)

Unraveling the Obesity and Breast Cancer Links: A Role for Cancer-Associated Adipocytes?

Dirat B.a–c · Bochet L.a–c · Escourrou G.d · Valet P.a,c · Muller C.a,b
aUniversity of Toulouse, bInstitute of Pharmacology and Structural Biology CNRS UMR 5089, cInstitut National de la Santé et de la Recherche médicale, INSERM U858 Equipe 3, IFR31, and dDepartment of Anatompathology and Cytology, CHU Rangueil, Toulouse, France

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: June 15, 2010
Cover Date: 2010

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9450-9 (Print)
eISBN: 978-3-8055-9451-6 (Online)

Abstract

In addition to diabetes and cardiovascular diseases, epidemiological evidence demonstrates that people who are obese or overweight are at increased risk of developing cancer – colon, breast (in postmenopausal women), endometrial or kidney cancer being among the most frequent. In addition to the increase in tumor occurrence, obesity also affects tumor prognosis, especially in breast and prostate cancers. In breast cancer, obesity is associated with reduced survival and increased recurrence independent of menopausal status. Host factors seem to contribute to the occurrence of tumors exhibiting an aggressive biology defined by advanced stages and high grade. Mature adipocytes are part of the breast cancer tissue and as highly endocrine cells susceptible to profoundly modify breast cancer cell behavior. Tumor progression has recently been recognized as the product of an evolving crosstalk between tumor cells and the surrounding ‘normal’ cells. We propose that such a bidirectional crosstalk exists between breast cancer cells and tumor-surrounding adipocytes, and that the tumor-modified adipocytes (or cancer-associated adipocytes) are key actors in tumor progression. The positive contribution of cancer-associated adipocytes into tumor progression might be amplified in obese women and explains at least in part the poor prognosis observed in this subset of patients.

© 2010 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: June 15, 2010
Cover Date: 2010

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9450-9 (Print)
eISBN: 978-3-8055-9451-6 (Online)


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