Two New Cases of Polysomy 13 in Canine Prostate CancerReimann-Berg N.a, b · Willenbrock S.a, b · Murua Escobar H.a · Eberle N.a · Gerhauser I.c · Mischke R.a · Bullerdiek J.a, b · Nolte I.a
aSmall Animal Clinic and Research Cluster REBIRTH, University of Veterinary Medicine Hannover, Hannover, bCenter for Human Genetics, University of Bremen, Bremen, cDepartment of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany
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Besides man, the dog is the only known mammalian species that spontaneously develops carcinomas of the prostate with considerable frequency. For this reason, the dog is considered to be the only useful animal model for spontaneously occurring prostate malignancies in man. Cytogenetic investigations of human prostate cancers have revealed the frequent occurrence of trisomies 7, 8, and 17. Chromosome analyses of canine prostate carcinomas are rare. In this report we present 2 cases of canine prostate cancer showing a clonal polysomy 13 along with complex karyotype changes. Along with a previous report demonstrating polysomy 13 as the only karyotype deviation in a canine prostate cancer the present report supports the hypothesis that in canine prostate cancer, polysomy 13 is a recurrent cytogenetic aberration linked to the development of the disease. As human chromosomes (HSA) 8q and 4q and the canine chromosome (CFA) 13 share high homology, these results suggest that a conserved area on these chromosomes is involved in tumorigenesis in both species.
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