Assessment of Sleep Impairment in Persistent Allergic Rhinitis Patients Using PolysomnographyMeng J. · Xuan J. · Qiao X. · Li X. · Liu S. · Lukat K.F. · Zhang N. · Bachert C.
aDepartment of Otorhinolaryngology, West China Hospital, Sichuan University, Sichuan, China; bUpper Airway Research Laboratory, Department of Otorhinolaryngology, University of Ghent, Ghent, Belgium
Background: Although questionnaires have demonstrated an association between impairment of quality of sleep and symptoms in allergic rhinitis (AR) patients, to date there is no report of an objective assessment of sleep in patients with persistent allergic rhinitis (PER) as defined by ARIA guidelines. The aim of the present study was therefore to assess sleep disturbance in PER patients by polysomnography (PSG). Methods: Ninety-eight PER patients with moderate-to-severe nasal obstruction and 30 healthy volunteers were included in the study. All patients underwent PSG during nocturnal sleep to assess the presence and severity of sleep disorders. Peak nasal inspiratory flow (PNIF) was also measured to assess nasal resistance. Results: There were statistically significant, though clinically modest, differences between PER patients and healthy controls in most PSG parameters including sleep efficiency, arousal index, average SaO2, lowest SaO2, time spent with a saturation below 90%, and snoring time. Although the apnea-hypopnea index (AHI) was not significantly different between the 2 groups, 17 subjects (17.3%) in the PER group but none of the control subjects had an AHI >5. Patients with higher T5SS scores (12 ≤ T5SS ≤ 15) had a greater tendency to snore than did patients with lower scores (8 ≤ T5SS ≤ 11). Finally, PNIF in the PER group was significantly lower than in the control group. Weak correlations between the arousal index and PNIF, average SaO2, and PNIF were found. Conclusion: PSG showed modest changes in PER patients versus control subjects.
Correspondence to: Prof. Dr. Shixi Liu
Department of Otorhinolaryngology, West China Hospital, Sichuan University
No. 37 Guo Xue Xiang, Chengdu
Sichuan 610041 (China)
Tel. +86 28 8542 2438, Fax +86 28 8542 3627, E-Mail firstname.lastname@example.org
J.M. and J.X. contributed equally to this work and should be considered first author and first coauthor.
Received: April 29, 2010
Accepted after revision: June 16, 2010
Published online: November 26, 2010
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 4, Number of References : 34
International Archives of Allergy and Immunology
Vol. 155, No. 1, Year 2011 (Cover Date: April 2011)
Journal Editor: Valenta R. (Vienna)
ISSN: 1018-2438 (Print), eISSN: 1423-0097 (Online)
For additional information: http://www.karger.com/IAA