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Table of Contents
Vol. 33, No. 4, 2010
Issue release date: August 2010
Section title: Original Paper
Kidney Blood Press Res 2010;33:251–259

Maternal Protein Restriction Reduces Angiotensin II AT1 and AT2 Receptor Expression in the Fetal Rat Kidney

Alwasel S.H.a · Kaleem I.b · Sahajpal V.b · Ashton N.b
aDepartment of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia; bFaculty of Life Sciences, University of Manchester, Manchester, UK
email Corresponding Author

Dr. Saleh Alwasel

Department of Zoology, College of Science, King Saud University

PO Box 2455

Riyadh 11451 (Saudi Arabia)

Tel. +966 0 5508 80848, E-Mail sawasel10@hotmail.com

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Maternal dietary protein restriction during pregnancy results in an increase in offspring blood pressure in the rat. The kidneys of the low protein (LP) rat have fewer nephrons, increased hemodynamic sensitivity to angiotensin II and lower glomerular filtration rate, suggesting altered activity of the renin-angiotensin system. Angiotensin II plays a role in nephrogenesis through the AT1 and AT2 receptor subtypes. The aim of this study was to determine expression levels of both subtypes during nephrogenesis. Pregnant Wistar rats were fed either a control 18% protein diet or a low 9% protein (LP) diet. A 35% reduction in nephron number (p < 0.05) associated with a 50% reduction in total glomerular volume (p < 0.001) was seen in LP rats. Renal AT1 (p < 0.0001) and AT2 (p < 0.0001) receptor protein expression were significantly lower in LP rats from E18 to day 10. AT1 expression in LP rat kidneys tended to increase over time while AT2 expression declined until day 10, when it began to increase again. Angiotensin II-regulated cell proliferation may be perturbed in the LP rat kidney during nephrogenesis which could contribute to the reduction in nephron number and the elevation in blood pressure observed in this model of programmed hypertension.

© 2010 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 03, 2009
Accepted: February 24, 2010
Published online: July 02, 2010
Issue release date: August 2010

Number of Print Pages: 9
Number of Figures: 5
Number of Tables: 2

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

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