Journal Mobile Options
Table of Contents
Vol. 17, No. 4, 2010
Issue release date: August 2010
Forsch Komplementmed 2010;17:189–194
Original Article · Originalarbeit

Protective Mechanisms of Moringa oleifera against CCl4-Induced Oxidative Stress in Precision-Cut Liver Slices

Sreelatha S.a · Padma P.R.b
aFaculty of Science, NUS, Singapore bDepartment of Biochemistry and Biotechnology, Avinashilingam University, Coimbatore, Tamil Nadu, India


Objective: The present study was designed to evaluate the efficacy of Moringa oleifera leaves against carbon tetrachloride (CCl4)-treated liver slices in vitro. Material and Methods: The study evaluated the antioxidant properties of Moringa oleifera leaves against CCl4-induced oxidative damage in liver slices. Results: CCl4 treatment significantly decreased the activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione S-transferase and caused decreased glutathione content and increased the thiobarbituric acid-reacting substances (TBARS). Treatment with Moringa oleifera extract increased the activities of antioxidant enzymes and glutathione content and reduced the levels of TBARS significantly. Observed reduction in the level of lipid peroxides showed a decreased tendency of peroxidative damage. Discussion and Conclusion: We conclude that, under these experimental conditions, the leaf extracts effectively suppress CCl4-induced oxidative stress. Our findings provide evidence to demonstrate that the possible mechanism of this activity may be due to the strong antioxidant property of the leaves.

 goto top of outline Author Contacts

Dr. Sarangapani Sreelatha, Faculty of Science, NUS, Singapore, Singapore 642274, Tel. +65 82834498,

 goto top of outline Article Information

Published online: July 30, 2010
Number of Print Pages : 6

 goto top of outline Publication Details

Forschende Komplementärmedizin / Research in Complementary Medicine (Research Practice Perspectives - Wissenschaft Praxis Perspektiven)

Vol. 17, No. 4, Year 2010 (Cover Date: August 2010)

Journal Editor: Walach H. (Frankfurt/O.)
ISSN: 1661-4119 (Print), eISSN: 1661-4127 (Online)

For additional information:

Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.