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Vol. 17, No. 4, 2010
Issue release date: August 2010
Section title: Original Article · Originalarbeit
Forsch Komplementmed 2010;17:189–194
(DOI:10.1159/000318606)

Protective Mechanisms of Moringa oleifera against CCl4-Induced Oxidative Stress in Precision-Cut Liver Slices

Sreelatha S. · Padma P.R.
aFaculty of Science, NUS, Singapore bDepartment of Biochemistry and Biotechnology, Avinashilingam University, Coimbatore, Tamil Nadu, India

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Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: 7/30/2010

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-4119 (Print)
eISSN: 1661-4127 (Online)

For additional information: http://www.karger.com/FOK

Abstract

Objective: The present study was designed to evaluate the efficacy of Moringa oleifera leaves against carbon tetrachloride (CCl4)-treated liver slices in vitro. Material and Methods: The study evaluated the antioxidant properties of Moringa oleifera leaves against CCl4-induced oxidative damage in liver slices. Results: CCl4 treatment significantly decreased the activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione S-transferase and caused decreased glutathione content and increased the thiobarbituric acid-reacting substances (TBARS). Treatment with Moringa oleifera extract increased the activities of antioxidant enzymes and glutathione content and reduced the levels of TBARS significantly. Observed reduction in the level of lipid peroxides showed a decreased tendency of peroxidative damage. Discussion and Conclusion: We conclude that, under these experimental conditions, the leaf extracts effectively suppress CCl4-induced oxidative stress. Our findings provide evidence to demonstrate that the possible mechanism of this activity may be due to the strong antioxidant property of the leaves.


  

Author Contacts

Dr. Sarangapani Sreelatha, Faculty of Science, NUS, Singapore, Singapore 642274, Tel. +65 82834498, sree_latha04yahoo.om

  

Article Information

Published online: July 30, 2010
Number of Print Pages : 6

  

Publication Details

Forschende Komplementärmedizin / Research in Complementary Medicine (Research Practice Perspectives - Wissenschaft Praxis Perspektiven)

Vol. 17, No. 4, Year 2010 (Cover Date: August 2010)

Journal Editor: Walach H. (Frankfurt/O.)
ISSN: 1661-4119 (Print), eISSN: 1661-4127 (Online)

For additional information: http://www.karger.com/FOK


Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: 7/30/2010

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-4119 (Print)
eISSN: 1661-4127 (Online)

For additional information: http://www.karger.com/FOK


Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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