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Vol. 155, No. 1, 2011
Issue release date: April 2011
Section title: Original Paper
Int Arch Allergy Immunol 2011;155:52–56
(DOI:10.1159/000318736)

Food-Specific IgG4 Lack Diagnostic Value in Adult Patients with Chronic Urticaria and Other Suspected Allergy Skin Symptoms

Antico A. · Pagani M. · Vescovi P.P. · Bonadonna P. · Senna G.
aAllergy Unit, Department of Internal Medicine, Azienda Istituti Ospedalieri C. Poma, Mantova, and bAllergy Unit, Azienda Ospedale Maggiore, Verona, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/15/2009
Accepted: 6/17/2010
Published online: 11/26/2010

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 3

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: Specific IgG4 dosing against food is proposed to the public by a lot of commercial laboratories as a reliable method to diagnose food intolerance. Actually, few data on IgG4 responses to foods in adults are available in the literature. In this study we evaluated the clinical utility of specific IgG4 dosing against food in adult patients with suspected food allergy/intolerance. Methods: A case series of 73 adult patients with suspected food allergy and clinical manifestations of chronic urticaria or other allergy-supposed skin symptoms were tested for specific IgG4 against foods. An open food challenge was carried out for all IgG4-positive food. All positive open tests were controlled by double-blind placebo-controlled food challenge. Results: Forty-five patients (62%) were IgG4 positive for a number of foods, mainly egg, milk, casein and wheat. None of the patients with IgG4-positive testing showed adverse reactions, neither immediate nor delayed, to the corresponding food. Conclusions: In adult patients, testing for specific IgG4 lacks clinical utility for the diagnosis of food allergy or intolerance. Dosing of IgG4 should not be part of the diagnosis and therapy of adult patients with allergy-like skin diseases.


  

Author Contacts

Correspondence to: Dr. Andrea Antico
Servizio di Allergologia, Ospedale Civile
Piazza 80° Fanteria, 1
IT–46041 Asola (Italy)
Tel. +39 037 672 1238, Fax +39 037 672 0189, E-Mail andrea.antico@aopoma.it

  

Article Information

Received: December 15, 2009
Accepted after revision: June 17, 2010
Published online: November 26, 2010
Number of Print Pages : 5
Number of Figures : 1, Number of Tables : 3, Number of References : 33

  

Publication Details

International Archives of Allergy and Immunology

Vol. 155, No. 1, Year 2011 (Cover Date: April 2011)

Journal Editor: Valenta R. (Vienna)
ISSN: 1018-2438 (Print), eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/15/2009
Accepted: 6/17/2010
Published online: 11/26/2010

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 3

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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