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Table of Contents
Vol. 116, No. 3, 2010
Issue release date: August 2010
Section title: Original Research
Cardiology 2010;116:178–182
(DOI:10.1159/000318810)

L-Carnitine Treatment in Patients with Mild Diastolic Heart Failure Is Associated with Improvement in Diastolic Function and Symptoms

Serati A.R. · Motamedi M.R. · Emami S. · Varedi P. · Movahed M.R.
aCardiovascular Research Center, Modarres Hospital, Tehran, bRadiology Department of Hazrat Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran; cSouthern Arizona VA Health Care System and University of Arizona Sarver Heart Center, Tucson, Ariz., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: 1/21/2010
Accepted: 3/29/2010
Published online: 7/16/2010

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 4

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD

Abstract

Objectives:L-Carnitine is a crucial component of activated fatty acid transport. The aim of this study was to evaluate the effect of L-carnitine on patients with a history of mild heart failure and diastolic dysfunction. Methods: Twenty-nine patients with a history of NYHA functional class II symptoms and ejection fraction >45% with documented grade 1 diastolic dysfunction on echocardiogram were randomized in blinded fashion to receive 1,500 mg of L-carnitine daily for 3 months in comparison to a no treatment group (31 patients). Baseline echocardiographic and follow-up measurements of diastolic parameters were assessed after 3 months. Results: Important parameters of diastolic function improved in the L-carnitine group only: left atrial size (3.6 ± 0.4 cm before treatment vs. 3.4 ± 0.5 cm after treatment, p = 0.01); isovolemic relaxation time (127 ± 26 ms before vs. 113 ± 24 ms after treatment, p = 0.007); septal mitral E′ velocity (0.064 ± 0.01 m/s before vs. 0.074 ± 0.01 m/s after treatment, p = 0.01), and lateral mitral E velocity (0.082 ± 0.01 m/s before vs. 0.091 ± 0.02 m/s after treatment, p = 0.006). Dyspnea also significantly improved in L-carnitine-treated patients. Conclusion: In patients with a history of diastolic heart failure, important indices of diastolic function and symptoms appear to improve with L-carnitine treatment.


  

Author Contacts

M. Reza Movahed, MD
Southern Arizona VA Health Care System
University of Arizona Sarver Heart Center
1501 North Campbell Avenue, Tucson, AZ 85724 (USA)
Tel. +1 520 626 8711, Fax +1 520 629 4636, E-Mail rmova@aol.com

  

Article Information

Received: January 21, 2010
Accepted after revision: March 29, 2010
Published online: July 16, 2010
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 4, Number of References : 30

  

Publication Details

Cardiology (International Journal of Cardiovascular Medicine, Surgery, Pathology and Pharmacology)

Vol. 116, No. 3, Year 2010 (Cover Date: August 2010)

Journal Editor: Borer J.S. (New York, N.Y.)
ISSN: 0008-6312 (Print), eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: 1/21/2010
Accepted: 3/29/2010
Published online: 7/16/2010

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 4

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


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