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Baseline Predictors of Clinical Progression among Patients with Dysexecutive Mild Cognitive ImpairmentJohnson J.K.a–c · Pa J.c · Boxer A.L.c · Kramer J.H.c · Freeman K.c · Yaffe K.c–e
aInstitute for Health and Aging, and Departments of bSocial and Behavioral Sciences, cNeurology, and dPsychiatry, Epidemiology and Biostatistics, University of California, and eVeteran’s Affairs Medical Center, San Francisco, Calif., USA Corresponding Author
Julene K. Johnson, PhD
UCSF Institute for Health and Aging
3333 California St., Suite 340
San Francisco, CA 94148 (USA)
Tel. +1 415 476 1106, Fax +1 415 502 5208, E-Mail Julene.Johnson@ucsf.edu
Background/Aims: There are few studies that evaluate the clinical outcomes of individuals with non-amnestic mild cognitive impairment (MCI). The purpose of this study was to evaluate baseline predictors of clinical progression after 2 years for patients with dysexecutive MCI (dMCI), a single-domain non-amnestic MCI subgroup. Methods:We evaluated clinical progression in a sample of 31 older adults with dMCI. Clinical progression was defined as a worsening on the Clinical Dementia Rating sum of boxes at the 2-year visit, whereas patients were classified as stable if the score did not worsen over 2 years. We compared baseline brain MRI, neuropsychological tests, and health risk factors. Results: Twelve individuals with dMCI progressed clinically, and 19 individuals remained stable over 2 years. Compared to the stable dMCI patients, the dMCI patients who progressed showed brain atrophy in the bilateral insula and left lateral temporal lobe on MRI. dMCI patients who progressed were also older, had lower baseline performance on category fluency and a spatial location task, and reported fewer dysexecutive symptoms. Health risk factors, except hypertension, did not differ between groups. Conclusion: The results suggest that dMCI patients who progress relatively quickly over 2 years may have unique clinical and brain MRI features.
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