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Vol. 4, No. 2, 2010
Issue release date: May – August
Section title: Published: August 2010

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Case Rep Gastroenterol 2010;4:286–292
(DOI:10.1159/000319545)

Hepatocellular Carcinoma with Foamy Histiocyte-Like Appearance: A Deceptively Clear Cell Carcinoma Appearing Variant

Noro T. · Gotohda N. · Kojima M. · Konishi M. · Nakaghori T. · Takahashi S. · Hasebe T. · Kinoshita T.
aDepartment of Hepatobiliary Pancreatic Surgery, bPathology Division, Research Center for Innovative Oncology, and cSurgical Pathology Section, Clinical Laboratory Division, National Cancer Center Hospital East, Kashiwa, Japan

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Abstract

Hepatocellular carcinoma (HCC) shows many pathological features, and it varies architecturally and cytologically. There have been many reports and discussions of the morphological features of HCC. A 63-year-old man was found to have a solitary tumor in liver segment 7 that was diagnosed as HCC. A partial resection of liver segment 7 was performed. Microscopically, the tumor lesion showed a moderately differentiated HCC. There was also a lesion with foamy histiocyte-like cells corresponding to the white lesion in the face of the cut tumor. Immunohistochemical staining showed that they were negative for CD68, S-100, vimentin, and HMB-45. The cytoplasm itself was negative on periodic acid Schiff (PAS) and Sudan staining. Without immunohistological analysis, it is difficult to distinguish this HCC variant from clear cell carcinoma or metastases of renal cell carcinoma. It is important to recognize this type as a specific cytological variant of HCC that requires confirmation by immunohistochemistry. This report describes the case of a patient with a morphologically distinctive pattern of HCC with prominent cell cytoplasm that had a foamy histiocyte-like appearance. To the best of our knowledge, this is the first report of this HCC variant.


  

Author Contacts

Takuji Noro, MD
Department of Surgery, International University of Health and Welfare Hospital
537-3 Iguchi Nasushiobara-shi, Tochigi 329-2763 (Japan)
Tel. +81 287 372 221, Fax +81 287 375 315, E-Mail tnoro@ihw.ac.jp

  

Article Information

Published online: August 3, 2010
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 1,

  

Publication Details

Case Reports in Gastroenterology

Vol. 4, No. 2, Year 2010 (Cover Date: May - August)

Journal Editor: Urrutia R. (Rochester, Minn.)
ISSN: NIL (Print), eISSN: 1662-0631 (Online)

For additional information: http://www.karger.com/CRG


Article / Publication Details

First-Page Preview
Abstract of Published: August 2010

Published online: 8/3/2010

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: (Print)
eISSN: 1662-0631 (Online)

For additional information: http://www.karger.com/CRG


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