Cover

Body Composition and Aging

Editor(s): Mobbs C.V. (New York, N.Y.) 
Hof P.R. (New York, N.Y.) 
Table of Contents
Vol. 37, No. , 2010
Section title: Paper
Mobbs CV, Hof PR (eds): Body Composition and Aging. Interdiscipl Top Gerontol. Basel, Karger, 2010, vol 37, pp 1–19
(DOI:10.1159/000319991)

Contribution of Adipose Tissue to Health Span and Longevity

Huffman D.M. · Barzilai N.
Departments of aMedicine, bGenetics and Institute for Aging Research, Albert Einstein College of Medicine, Bronx, N.Y., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 8/10/2010
Cover Date: 2010

Number of Print Pages: 19
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9521-6 (Print)
eISBN: 978-3-8055-9522-3 (Online)

Abstract

Adipose tissue accounts for approximately 20% (lean) to >50% (in extreme obesity) of body mass and is biologically active through its secretion of numerous peptides and release and storage of nutrients such as free fatty acids. Studies in rodents and humans have revealed that body fat distribution, including visceral fat (VF), subcutaneous (SC) fat and ectopic fat are critical for determining the risk posed by obesity. Specific depletion or expansion of the VF depot using genetic or surgical strategies in animal models has proven to have direct effects on metabolic characteristics and disease risk. In humans, there is compelling evidence that abdominal obesity most strongly predicts mortality risk, while in rats, surgical removal of VF improves mean and maximum life span. There is also growing evidence that fat deposition in ectopic depots such as skeletal muscle and liver can cause lipotoxicity and impair insulin action. Conversely, expansion of SC adipose tissue may confer protection from metabolic derangements by serving as a ‘metabolic sink’ to limit both systemic lipids and the accrual of visceral and ectopic fat. Treatments targeting the prevention of fat accrual in these harmful depots should be considered as a primary target for improving human health span and longevity.


  

Author Contacts

Nir Barzilai, MD, Institute for Aging Research, Departments of Medicine and Molecular Biology, Belfer Building, Suite 701, The Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461 (USA)Tel.+. +1 718 430 3312, Fax +1 718 430 8557, E-Mail barzilai@aecom.yu.edu

  

Article Information

Published online: August 10, 2010
Number of Print Pages : 19

  

Publication Details

Book Serie: Interdisciplinary Topics in Gerontology, Vol. 37, Year 2010

Editor(s): Hof, P.R. (New York, N.Y.); Mobbs, C.V. (New York, N.Y.)
ISSN: 0074-1132 (Print), eISSN: 1662-3800 (Online)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=0074-1132

Book Title: Body Composition and Aging

Editor(s): Mobbs CV, Hof PR (eds)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=0074-1132&volume=37


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 8/10/2010
Cover Date: 2010

Number of Print Pages: 19
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9521-6 (Print)
eISBN: 978-3-8055-9522-3 (Online)


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