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Vol. 56, No. 4, 2010
Issue release date: August 2010
Section title: Clinical Study
Chemotherapy 2010;56:298–302
(DOI:10.1159/000320030)

Effect of Vitamin C on Lipidperoxidation and Antioxidant Status in Tamoxifen-Treated Breast Cancer Patients

Muralikrishnan G.a · Amanullah S.c · Basha M.I.d · Boopalan S.b · Vijayakumar S.b · Shakeel F.e
aDepartment of Biochemistry, Guindy Campus, University of Madras, Madras, and bCancer Research Center, Arignar Anna Cancer Hospital, Kancheepuram, India; Departments of cBiochemistry, dAnatomy, Faculty of Medicine and eDepartment of Pharmaceutics, Faculty of Pharmacy, Al-Arab Medical University, Benghazi, Libya

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 1/18/2010
Accepted: 3/24/2010
Published online: 8/13/2010
Issue release date: August 2010

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE

Abstract

Background: Vitamin C is a water-soluble chain-breaking antioxidant that has beneficial effects on lipid-metabolizing enzymes. In the present study, the level of thiobarbituric acid (TBA) substances and antioxidant enzymes such as catalase, superoxide dismutase (SOD), glutathione peroxidase and glutathione-S-transferase were assayed. Methods: The level of TBA substances and antioxidant enzymes was determined in plasma and RBC hemolysates, respectively, in 60 postmenopausal women with breast cancer. Results: The data obtained from the study revealed that the levels of TBA and the antioxidant enzymes catalase, SOD, glutathine peroxidase and glutathine-S-transferse were significantly normalized by vitamin C treatment in the RBC hemolysate. Conclusion: The results compared vitamin C-treated breast cancer patients with normal individuals and showed that co-administration of vitamin C is more beneficial in breast cancer patients treated with tamoxifen.

© 2010 S. Karger AG, Basel


  

Author Contacts

Dr. Faiyaz Shakeel
Department of Pharmaceutics, Faculty of Pharmacy
Al-Arab Medical University
Benghazi (Libya)
Tel. +218 91 389 9028, Fax +218 61 222 1152, E-Mail faiyazs@fastmail.fm

  

Article Information

Received: January 18, 2010
Accepted after revision: March 24, 2010
Published online: August 13, 2010
Number of Print Pages : 5
Number of Figures : 2, Number of Tables : 0, Number of References : 36

  

Publication Details

Chemotherapy (International Journal of Experimental and Clinical Chemotherapy)

Vol. 56, No. 4, Year 2010 (Cover Date: August 2010)

Journal Editor: Sörgel F. (Nürnberg-Heroldsberg)
ISSN: 0009-3157 (Print), eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 1/18/2010
Accepted: 3/24/2010
Published online: 8/13/2010
Issue release date: August 2010

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE


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