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Vol. 100, No. 1, 2011
Issue release date: June 2011
Section title: Original Paper
Neonatology 2011;100:14–22
(DOI:10.1159/000320155)

Mortality of Neonatal Respiratory Failure Related to Socioeconomic Factors in Hebei Province of China

Ma L. · Liu C. · Wang Y. · Li S. · Zhai S. · Gu X. · Liu F. · Yan A. · Guo W. · Li Y. · Xiao M. · Yin J. · Li Y. · Liu X. · Wang R. · Kirpalani H. · Sun B. · Hebei Neonatal Network Study Group
aDepartment of Pediatrics, Children’s Hospital of Fudan University, Shanghai, Departments of Neonatology, bHebei Provincial Children’s Hospital, Shijiazhuang, cBaoding Women’s and Children’s Hospital, Baoding, dHandan Women’s and Children’s Hospital, Handan, eHandan City Central Hospital, Handan, fChina National Petroleum Corporation Central Hospital, Langfang, gBethune International Peace Hospital, Shijiazhuang, hQinhuangdao Women’s and Children’s Hospital, Qinhuangdao, iXingtai City People’s Hospital, Xingtai, jTangshan Women’s and Children’s Hospital, Tangshan, kCangzhou City Central Hospital, Cangzho, lHebei Provincial General Hospital, Shijiazhuang, mSecond Hospital of Hebei Medical University, Shijiazhuang, nChengde Medical College Hospital, Chengde, and oCangzhou City People’s Hospital, Cangzhou, China; pDepartment of Neonatology, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pa., USA; Department of Clinical Epidemiology, McMaster University Health Science Center, Hamilton, Ont., Canada

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/9/2010
Accepted: 7/21/2010
Published online: 12/10/2010

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 5

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

Dramatic progress has occurred in neonatal intensive care in tertiary centers in mid-eastern China. We investigated the characteristics of neonatal respiratory failure (NRF) including the incidence, management, outcomes and costs in 14 neonatal intensive care units (NICUs) of Hebei, a province at an intermediate economic level in China. Over a period of 12 consecutive months in 2007–2008, perinatal data were collected prospectively from all NICU admissions (n = 11,100). NRF was defined as severe hypoxemia requiring respiratory support for more than 24 h, and was diagnosed in 1,875 newborns (16.9%). The average birth weight of newborns with NRF was 2,200 g (range 600–5,500 g), with 60.9% <2,500 g, and 2% <1,000 g. The male:female ratio was 2.6:1. The leading diagnosis was respiratory distress syndrome; 58.3% of newborns with respiratory distress syndrome received surfactant. Continuous positive airway pressure was used more than ventilation (73.3 vs. 49.1%,p < 0.001). Overall, the mortality rate until discharge was 31.4% (583/1,859). Most deaths (432, 74.1%) followed a parental decision to withdraw care. NRF mortality varied in association with different gross domestic product levels, family annual income and nurse-to-bed ratios. The median cost of a hospital stay was 10,169 CNY (interquartile range: 6,745–16,386) for NRF survivors. We conclude that, despite the available respiratory support in these emerging NICUs, the mortality of NRF remains. This was associated with prematurity, standard of care but also with socioeconomic factors affecting treatment decisions. Assessment of efficacy of respiratory support for NRF in such emerging neonatal services should account for both standard of care and socioeconomic conditions.


  

Author Contacts

Bo Sun, MD, PhD
Department of Pediatrics, Children’s Hospital of Fudan University
399 Wanyuan Road, Shanghai 201102 (China)
Tel./Fax +86 21 6493 1217
E-Mail bsun@shmu.edu.cn or qyang75@yahoo.com.cn

  

Article Information

Received: March 9, 2010
Accepted after revision: July 21, 2010
Published online: December 10, 2010
Number of Print Pages : 9
Number of Figures : 0, Number of Tables : 5, Number of References : 19

  

Publication Details

Neonatology (Fetal and Neonatal Research)

Vol. 100, No. 1, Year 2011 (Cover Date: June 2011)

Journal Editor: Halliday H.L. (Belfast), Speer C.P. (Würzburg)
ISSN: 1661-7800 (Print), eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/9/2010
Accepted: 7/21/2010
Published online: 12/10/2010

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 5

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


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