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Table of Contents
Vol. 79, No. 3-4, 2010
Issue release date: March 2011
Section title: Clinical Translational Research
Oncology 2010;79:187–196
(DOI:10.1159/000320609)

Immunological Effects of Bevacizumab-Based Treatment in Metastatic Colorectal Cancer

Manzoni M.a · Rovati B.a · Ronzoni M.c · Loupakis F.d · Mariucci S.a · Ricci V.c · Gattoni E.a · Salvatore L.d · Tinelli C.b · Villa E.c · Danova M.a
aMedical Oncology, and bBiometry and Clinical Epidemiology Unit, Foundation IRCCS Policlinico S. Matteo, Pavia, cMedical Oncology, Scientific Institute S. Raffaele, Milano, and dMedical Oncology 2, Department of Oncology, University Hospital of Pisa, Pisa, Italy

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Article / Publication Details

First-Page Preview
Abstract of Clinical Translational Research

Received: June 11, 2010
Accepted: July 27, 2010
Published online: February 28, 2011
Issue release date: March 2011

Number of Print Pages: 10
Number of Figures: 4
Number of Tables: 3

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Objective: The efficacy of bevacizumab in metastatic colorectal cancer (mCRC) could be related not only to its well-known antiangiogenetic properties but also to a hypothetical effect on the immune system of the host. Methods: We enrolled mCRC patients treated with a bevacizumab-based first-line therapy. Lymphocyte and dendritic cell subsets were evaluated at baseline, 3rd and 6th cycle. The clinical efficacy was estimated as response rate and progression-free survival. Forty healthy subjects were used as reference. Results: Fifty-one patients were enrolled. In comparison with healthy subjects, they showed a decrease of T and B cell compartments. Bevacizumab ameliorated the impairment of lymphocyte subsets, especially for T cells. Responders showed a trend toward an increase of CD3 (p = 0.07) and CD4 (p = 0.05). Among patients with a progression-free survival >1 year, only CD19 (p = 0.033) and CD20 (p = 0.013) showed a significant increase. No baseline impairment and no significant modification of dendritic cells were found. Conclusion: Bevacizumab-based therapy is able to increase B and T cell compartments. The expansion of T lymphocytes could imply an amelioration of dendritic cell-presenting capacity. These effects correlate with a more favourable clinical outcome and could be taken into account in clinical protocols aimed at combining antiangiogenetic-therapy with immunotherapy in mCRC.

© 2011 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical Translational Research

Received: June 11, 2010
Accepted: July 27, 2010
Published online: February 28, 2011
Issue release date: March 2011

Number of Print Pages: 10
Number of Figures: 4
Number of Tables: 3

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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