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Clotting Factors and Eicosanoids Protect against Nematode InfectionsHyrsl P.a, b · Dobes P.a, b · Wang Z.a · Hauling T.a · Wilhelmsson C.a · Theopold U.a
aDepartment of Molecular Biology and Functional Genomics, Stockholm University, Stockholm, Sweden; bDepartment of Animal Physiology and Immunology, Institute of Experimental Biology, Masaryk University, Brno, Czech Republic Corresponding Author
Dr. Ulrich Theopold
Department of Molecular Biology and Functional Genomics
University of Stockholm
SE–10691 Stockholm (Sweden)
Tel. +46 816 4181, Fax +46 816 6488, E-Mail firstname.lastname@example.org
We show that hemolymph clotting protects Drosophila melanogaster against infections with an entomopathogenic nematode and its symbiotic bacterium. We also provide biochemical and genetic evidence for an involvement of eicosanoids in the same infection model. Taken together, our results confirm the conserved nature of the immune function of clot formation.
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