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Vol. 71, No. 1, 2011
Issue release date: January 2011
Section title: Original Article
Gynecol Obstet Invest 2011;71:59–65
(DOI:10.1159/000320747)

A Randomized Comparison of Droperidol, Metoclopramide, Tropisetron, and Ondansetron for the Prevention of Postoperative Nausea and Vomiting

Ekinci O. · Malat I. · Işıtmangil G. · Aydın N.
Department of Anesthesiology, Haydarpaşa Numune Hospital for Research and Training, Istanbul, Turkey

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: 9/17/2009
Accepted: 4/21/2010
Published online: 12/15/2010
Issue release date: January 2011

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 5

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI

Abstract

Background: Nausea and vomiting are the most common causes of postoperative complications, and they are seen most often after operations performed using general anesthesia and sedation. We designed this study to compare the effects of droperidol, metoclopramide, tropisetron, and ondansetron for the prevention of postoperative nausea and vomiting in patients undergoing gynecologic operations. Methods: One hundred patients were randomly assigned to 1 of 5 groups: group D was given 2.5 mg droperidol; group M, 10 mg metoclopramide; group T, 2.5 mg tropisetron; group O, 4 mg ondansetron 5 min after induction, and group C was the control group and received no prophylactic antiemetic treatment. All patients were observed for sedation and postoperative nausea and vomiting for 48 h. Results: Within 24 h after the operation, severe postoperative nausea and vomiting were seen in 4 patients (20%) in group D, 8 (40%) in group M, 5 (25%) in group T, 3 (15%) in group O, and 12 patients (60%) in the control group. Patients receiving droperidol, tropisetron, and ondansetron had significantly less serious emesis than the control group (p < 0.05). Sedation was seen in 5 patients receiving droperidol (4 patients score 2; and 1 patient score 3) and tropisetron (2 patients score 2; and 3 patients score 3) 15 min after surgery; this was significantly higher than in the control group (p < 0.05). Conclusion: We conclude that metoclopramide is not effective in preventing postoperative nausea and vomiting after gynecologic operations. Droperidol, tropisetron, and ondansetron are effective; however, the sedating effects of droperidol and tropisetron should be considered.

© 2010 S. Karger AG, Basel


  

Author Contacts

Osman Ekinci
Department of Anesthesiology
Haydarpaşa Numune Hospital for Research and Training
TR–34668 Istanbul (Turkey)
Tel. +90 505 640 5794, Fax +90 216 346 05 82, E-Mail droekinci@mynet.com

  

Article Information

Received: September 9, 2009
Accepted after revision: April 21, 2010
Published online: December 15, 2010
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 5, Number of References : 35

  

Publication Details

Gynecologic and Obstetric Investigation

Vol. 71, No. 1, Year 2011 (Cover Date: January 2011)

Journal Editor: D'Hooghe T. (Leuven)
ISSN: 0378-7346 (Print), eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: 9/17/2009
Accepted: 4/21/2010
Published online: 12/15/2010
Issue release date: January 2011

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 5

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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