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Table of Contents
Vol. 24, No. 2, 2011
Issue release date: January 2011
Section title: Original Paper
Skin Pharmacol Physiol 2011;24:67–74
(DOI:10.1159/000321442)

Supplementation of Flaxseed Oil Diminishes Skin Sensitivity and Improves Skin Barrier Function and Condition

Neukam K.a · De Spirt S.a · Stahl W.a · Bejot M.c · Maurette J.-M.c · Tronnier H.b · Heinrich U.b
aInstitute of Biochemistry and Molecular Biology I, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, and bInstitute of Experimental Dermatology, University Witten-Herdecke, Witten, Germany; cLaboratoire Oenobiol, Paris, France

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 25, 2010
Accepted: September 10, 2010
Published online: November 18, 2010
Issue release date: January 2011

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 3

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

Background: Skin sensitivity is a common problem in the Western population correlated with changes of skin properties like skin barrier function, hydration and skin physiology. Skin properties can be modulated by dietary fatty acids (FA), especially poly-unsaturated FA. The present study was performed to evaluate the effect of daily supplementation with flaxseed oil and safflowerseed oil on healthy volunteers with sensitive skin. Methods: The study was designed as a randomized, double-blind 12-week intervention with 2 female treatment groups (n = 13). Plasma FA profile, skin sensitivity, skin hydration, transepidermal water loss (TEWL) and skin surface were evaluated on day 0, week 6 and week 12. Results: Supplementation with flaxseed oil led to significant decreases in sensitivity (after nicotinate irritation), TEWL, skin roughness and scaling, while smoothness and hydration were increased. Concomitantly, the ratio of n–6/n–3 FA in plasma decreased. Upon supplementation with safflowerseed oil, only a significant improvement in skin roughness and hydration was observed; however, the effects were less pronounced and determined at a later point in time than with flaxseed oil. The plasma n–6/n–3 FA ratio increased. Conclusion: The data provide evidence that daily intake of flaxseed oil modulates skin condition.

© 2010 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 25, 2010
Accepted: September 10, 2010
Published online: November 18, 2010
Issue release date: January 2011

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 3

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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