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Interferon Alone or Combined with Ribavirin for Acute Prolonged Infection with Hepatitis C Virus in ChimpanzeesTomoguri T.a · Katayama K.b · Tanaka J.b · Yugi H.d · Mizui M.c · Miyakawa Y.e · Yoshizawa H.b
aSanwa Kagaku Kenkyusho Co., Ltd., Kumamoto, bDepartment of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical Sciences, Hiroshima University, and cJapanese Red Cross Hiroshima Blood Center, Hiroshima, dDivision of Nucleic Acid Amplification Test (NAT), Japanese Red Cross Tokyo Blood Center, and eMiyakawa Memorial Research Foundation, Tokyo, Japan Corresponding Author
Junko Tanaka, PhD
Department of Epidemiology, Infectious Disease Control and Prevention
Graduate School of Biomedical Sciences, Hiroshima University
Kasumi 1-2-3, Minami-Ku, Hiroshima 734-8551 (Japan)
Tel. +81 82 257 5161, Fax +81 82 257 5164, E-Mail firstname.lastname@example.org
Infection with hepatitis C virus (HCV) persisted for longer than 29 weeks in 2 chimpanzees after they had been inoculated with it experimentally. One of them (C-210) received short-term subcutaneous interferon-α (IFN-α) 6 million units (MU) daily for 7 days at week 29. He cleared HCV RNA from the serum and remained negative for it during 25 weeks after the withdrawal of IFN. The other (C-224) did not respond to 2 courses of a short-term IFN monotherapy at weeks 20 and 23. Twelve weeks thereafter, he received IFN-α 3 MU daily for 2 weeks and then 3 times a week for 14 weeks combined with oral ribavirin 600 mg daily during 16 weeks. HCV RNA disappeared from the serum and stayed negative until the last follow-up 24 weeks after the completion of combination therapy.
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