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Table of Contents
Vol. 8, No. 4, 2011
Issue release date: May 2011
Section title: Review
Neurodegenerative Dis 2011;8:155–168
(DOI:10.1159/000321548)

Protective Role of Heat Shock Proteins in Parkinson’s Disease

Aridon P.a · Geraci F.b · Turturici G.b · D’Amelio M.a · Savettieri G.a · Sconzo G.b
aBiomedicina Sperimentale e Neuroscienze Cliniche, e bDipartimento di Biologia Cellulare e dello Sviluppo, Alberto Monroy, Università di Palermo, Palermo, Italia

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: April 16, 2010
Accepted: September 16, 2010
Published online: January 05, 2011
Issue release date: May 2011

Number of Print Pages: 14
Number of Figures: 1
Number of Tables: 2

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD

Abstract

Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease. Despite a large amount of research, the pathogenetic mechanism of these diseases has not yet been clarified. Abnormal protein folding, oxidative stress, mitochondrial dysfunction, and apoptotic mechanisms have all been reported as causes of neurodegenerative diseases in association with neuroinflammatory mechanisms which, by generating deleterious molecules, could promote the cascade of events leading to neurodegeneration. Heat shock proteins (HSPs) play a central role in preventing protein misfolding and inhibiting apoptotic activity, and represent a class of proteins potentially involved in PD pathogenesis. The present review will focus on two HSPs, HSP70 and HSP90, with the aim of specifying their role in PD pathogenesis.

© 2011 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Review

Received: April 16, 2010
Accepted: September 16, 2010
Published online: January 05, 2011
Issue release date: May 2011

Number of Print Pages: 14
Number of Figures: 1
Number of Tables: 2

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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