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Table of Contents
Vol. 155, No. 4, 2011
Issue release date: July 2011
Section title: Short Communication
Int Arch Allergy Immunol 2011;155:355–360
(DOI:10.1159/000321614)

Effects of Antihistamines on Innate Immune Responses to Severe Bacterial Infection in Mice

Metz M.a · Doyle E.a · Bindslev-Jensen C.b · Watanabe T.c · Zuberbier T.a · Maurer M.a, b
aDepartment of Dermatology and Allergy, Allergie-Centrum-Charité, Charité – Universitätsmedizin Berlin, Berlin, Germany; bDepartment of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark; cGraduate School of Medicine, Kyoto University, Kyoto, Japan

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Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: August 18, 2010
Accepted: September 29, 2010
Published online: February 22, 2011
Issue release date: July 2011

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: Sedating and non-sedating histamine H1 receptor (H1R) antagonists and H2R blockers are widely used drugs which are generally considered to be safe medications. However, recently, these drugs have been shown to possibly impair the outcome of perforating appendicitis in children. Objective: It was the aim of this study to characterize the effects of histamine receptor blockade in severe bacterial infections in more detail. Methods: To obtain information on the safety of histamine receptor blockade in more detail, we used pharmacological and genetic approaches targeting histamine receptors and performed cecal ligation and puncture (CLP), a mouse model of septic peritonitis. After induction of septic peritonitis, morbidity and mortality were monitored closely. Results: Here, we show that oral treatment with first-generation H1R antihistamine diphenhydramine, H2R blocker cimetidine and H3/4R blocker thioperamide impairs optimal innate immune responses in severe murine bacterial sepsis. However, these adverse effects are not mediated by H1R, as mice deficient for H1R show similar rates of morbidity and mortality after CLP as their wild-type controls. Similarly, the second-generation antihistamine desloratadine neither affects morbidity nor mortality after CLP. Conclusion: Our findings indicate that sedating first-generation H1R antihistamines and H2R blockers might impair innate immune responses to bacteria and that these drugs should be used with caution in patients with severe bacterial infections.

© 2011 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: August 18, 2010
Accepted: September 29, 2010
Published online: February 22, 2011
Issue release date: July 2011

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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