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Original Paper

Effect of Prothrombin Complex Concentrate on Hematoma Enlargement and Clinical Outcome in Patients with Anticoagulant-Associated Intracerebral Hemorrhage

Kuwashiro T.a · Yasaka M.a, b · Itabashi R.a · Nakagaki H.a · Miyashita F.a · Naritomi H.a · Minematsu K.a

Author affiliations

aDepartment of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, and bDepartment of Cerebrovascular Disease, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan

Related Articles for ""

Cerebrovasc Dis 2011;31:170–176

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 06, 2010
Accepted: September 27, 2010
Published online: December 03, 2010
Issue release date: January 2011

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 5

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Background: The present study was carried out to determine the effect of prothrombin complex concentrate (PCC) on hematoma enlargement (HE) and the early clinical outcome of intracerebral hemorrhage (ICH) patients on long-term warfarin treatment. Methods: Themedical records and computed tomography (CT) images of 50 consecutive ICH patients on long-term warfarin treatment (35 men, 15 women; 69 ± 12 years old) were reviewed. International normalized ratio (INR) values, frequency of HE and clinical outcome were compared between patients treated with and without PCC. Results: INR values on admission were above 2.0 in 37 patients, of whom 19 were given PCC (PCC group) and 18 were not given PCC (control group). In these 37 patients, the frequency of HE (p = 0.017), the number of patients with a poor clinical outcome (modified Rankin Scale score ≧3 at 30 days or at discharge; p = 0.045) and in-hospital mortality (p = 0.042) were significantly higher in the control than in the PCC group. On multivariate logistic regression analysis with adjustment, PCC administration was independently associated (odds ratio 0.03, 95% confidence interval 0.00–0.63; p = 0.023) with a reduction in poor clinical outcome in ICH patients whose INR values were >2.0 on admission. Conclusions: Immediate INR reversal with PCC may prevent HE and subsequent poor outcome.

© 2010 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 06, 2010
Accepted: September 27, 2010
Published online: December 03, 2010
Issue release date: January 2011

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 5

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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