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Table of Contents
Vol. 156, No. 1, 2011
Issue release date: August 2011
Section title: Short Communication
Int Arch Allergy Immunol 2011;156:99–103
(DOI:10.1159/000321919)

Increased S-Nitrosothiol Levels in Nonasthmatic Eosinophilic Bronchitis Compared with Cough Variant Asthma

Lee B.-J.a · Jeung Y.-J.b · Lee J.-Y.a · Choi D.-C.a
aDepartment of Medicine and bCenter for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: July 01, 2010
Accepted: October 04, 2010
Published online: March 30, 2011
Issue release date: August 2011

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: Nonasthmatic eosinophilic bronchitis (NAEB) and cough variant asthma (CVA) are common causes of chronic cough. Both are characterized by eosinophilic inflammation in the airways. However, airway hyperresponsiveness, which is a characteristic feature of CVA, is not observed in NAEB. We hypothesized that endogenous bronchodilator S-nitrosothiol (SNO) levels are different between patients with NAEB and CVA. Methods: SNO concentrations in sputum supernatant were measured using a commercially available kit in 20 NAEB and 21 CVA patients. Results: The mean sputum eosinophil counts and exhaled nitric oxide values were similar in patients with NAEB (12.4 ± 2.3%, 80.6 ± 8.1 ppb) and CVA (15.3 ± 3.7%, 97.7 ± 9.2 ppb). By contrast, SNO levels in the airway lining fluid of NAEB patients were substantially higher than those of CVA patients (87.1 ± 9.8 vs. 46.8 ± 4.8 µM; p < 0.05). Conclusions: SNOs may be an important factor in determining the development of airway hyperresponsiveness in the presence of eosinophilic inflammation.

© 2011 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: July 01, 2010
Accepted: October 04, 2010
Published online: March 30, 2011
Issue release date: August 2011

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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