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Vol. 45, No. 1, 2011
Issue release date: April 2011
Section title: Original Paper
Caries Res 2011;45:13–20
(DOI:10.1159/000322300)

Inhibition of Dental Erosion by Casein and Casein-Derived Proteins

White A.J. · Gracia L.H. · Barbour M.E.
aSchool of Oral and Dental Sciences, University of Bristol, Bristol, and bGlaxoSmithKline Consumer Healthcare R&D, Weybridge, UK

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/20/2010
Accepted: 10/25/2010
Published online: 12/11/2010

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 1

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: http://www.karger.com/CRE

Abstract

The application of milk-derived proteins such as casein as anti-erosion agents in oral healthcare products is of current interest. The aim of this study was to investigate the potential of 3 commercially available, milk-derived proteins as agents to inhibit enamel erosion. Aqueous solutions of 0.5% w/v casein, casein phosphopeptide (CPP) or glycomacropeptide (GMP) with and without 300 ppm fluoride (F, as NaF) were investigated with regard to enamel softening and tissue loss, in comparison with a deionised water (DIW) negative control and 300 ppm F positive control. Casein and F reduced enamel surface softening compared to DIW, but CPP and GMP did not (DIW: 58.2% reduction in hardness; F: 13.3%; casein: 21.8%; CPP: 50.8%; GMP: 62.4%). Similar results were obtained with solutions containing protein and F, and the effects were statistically indistinguishable from protein alone (casein + F: 19.1%; CPP + F: 48.2%; GMP + F: 66.1%). By contrast, all protein solutions and F significantly reduced tissue loss (p < 0.050; DIW: 25.8 µm tissue loss; F: 21.6 µm; casein: 20.3 µm; CPP: 20.5 µm; GMP: 20.0 µm). Solutions containing protein and F reduced erosion more than protein alone, but this difference was only significant from protein alone for casein (casein + F: 12.2 µm; CPP + F: 17.3 µm; GMP + F: 18.2 µm). Casein and casein-derived proteins may therefore have the potential to act as agents to reduce or prevent enamel erosion. Furthermore, the erosion-reducing efficacy is not reduced by F, and is in some cases enhanced.


  

Author Contacts

Michele E. Barbour
School of Oral and Dental Sciences, University of Bristol
Lower Maudlin Street
Bristol, BS1 2LY (UK)
Tel. +44 117 342 4184, Fax +44 117 342 4443, E-Mail m.e.barbour@bristol.ac.uk

  

Article Information

Received: July 20, 2010
Accepted after revision: October 25, 2010
Published online: December 11, 2010
Number of Print Pages : 8
Number of Figures : 2, Number of Tables : 1, Number of References : 45

  

Publication Details

Caries Research

Vol. 45, No. 1, Year 2011 (Cover Date: April 2011)

Journal Editor: Beighton D. (London)
ISSN: 0008-6568 (Print), eISSN: 1421-976X (Online)

For additional information: http://www.karger.com/CRE


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/20/2010
Accepted: 10/25/2010
Published online: 12/11/2010

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 1

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: http://www.karger.com/CRE


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