rs5848 Variant of Progranulin Gene Is a Risk of Alzheimer’s Disease in the Taiwanese PopulationLee M.-J. · Chen T.-F. · Cheng T.-W. · Chiu M.-J.
aDepartment of Neurology, National Taiwan University Hospital, College of Medicine, and Departments of bPsychology and cNeurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan, ROC
Progranulin is the precursor of granulins, and its downregulation may lead to neurodegeneration. The single-nucleotide polymorphism rs5848 increases the risk of Alzheimer’s disease (AD). We explored the association between alleles of rs5848 and the risk of AD in the Taiwanese population. The frequency of the homozygous TT genotype (16.4 vs. 10.0%) increased in AD subjects by an odds ratio (OR) of 1.87 (p = 0.03) corrected for APOE ε4, age and gender. Interaction between age and homozygous TT genotype accentuated the risk of AD (OR 4.44, p < 0.001). The homozygous TT genotype of rs5848 may play a role in the genetic risk of AD development, especially in the elderly.
Dr. Ming-Jang Chiu
Department of Neurology
National Taiwan University Hospital
No. 7, Chung-Shan S. Road, Taipei 100, Taiwan (ROC)
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M.-J. Lee and T.-F. Chen contributed equally to this article.
Received: May 27, 2010
Accepted after revision: November 4, 2010
Published online: January 7, 2011
Number of Print Pages : 5
Number of Figures : 1, Number of Tables : 2, Number of References : 13
Vol. 8, No. 4, Year 2011 (Cover Date: May 2011)
Journal Editor: Nitsch R.M. (Zürich), Hock C. (Zürich)
ISSN: 1660-2854 (Print), eISSN: 1660-2862 (Online)
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