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Vol. 16, No. 6, 2011
Issue release date: September 2011
Section title: Original Paper
Audiol Neurotol 2011;16:388–397
(DOI:10.1159/000322641)

Safety of Intratympanic Injection of AM-101 in Patients with Acute Inner Ear Tinnitus

Muehlmeier G. · Biesinger E. · Maier H.
aDepartment of ENT, Head and Neck Surgery, German Armed Forces Hospital Ulm, Ulm, and bENT Clinic and Otolaryngology Department of Klinikum Traunstein, Traunstein, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/16/2010
Accepted: 2/11/2010
Published online: 1/21/2011

Number of Print Pages: 10
Number of Figures: 1
Number of Tables: 3

ISSN: 1420-3030 (Print)
eISSN: 1421-9700 (Online)

For additional information: http://www.karger.com/AUD

Abstract

Effective pharmacological treatments for tinnitus have proven elusive. Emerging evidence suggests that dysregulation of cochlear N-methyl-D-aspartate (NMDA) receptors may underlie aberrant excitation of the auditory nerve, which in turn is perceived as tinnitus. The blocking of these receptors thus represents a promising therapeutic approach. In a recent phase I/II clinical trial, the safety and local tolerance of intratympanic injections of the NMDA receptor antagonist AM-101 was evaluated for the first time in humans. The results from the double-blind, randomized, placebo-controlled study show that intratympanically injected AM-101 was well tolerated by study participants, and provided the first indications of therapeutic efficacy.


  

Author Contacts

Guido Muehlmeier, MD
German Armed Forces Hospital Ulm
Department for ENT, Head and Neck Surgery, Oberer Eselsberg 40
DE–89081 Ulm (Germany)
Tel. +49 731 1710 1501, E-Mail gment@t-online.de

  

Article Information

Received: August 16, 2010
Accepted after revision: November 2, 2010
Published online: January 21, 2011
Number of Print Pages : 10
Number of Figures : 1, Number of Tables : 3, Number of References : 35

  

Publication Details

Audiology and Neurotology (The Science of Hearing and Balance)

Vol. 16, No. 6, Year 2011 (Cover Date: September 2011)

Journal Editor: Harris J.P. (San Diego, Calif.)
ISSN: 1420-3030 (Print), eISSN: 1421-9700 (Online)

For additional information: http://www.karger.com/AUD


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/16/2010
Accepted: 2/11/2010
Published online: 1/21/2011

Number of Print Pages: 10
Number of Figures: 1
Number of Tables: 3

ISSN: 1420-3030 (Print)
eISSN: 1421-9700 (Online)

For additional information: http://www.karger.com/AUD


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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