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Vol. 86, No. 3, 2011
Issue release date: April 2011
Section title: Original Paper
Urol Int 2011;86:284–289
(DOI:10.1159/000322645)

Long-Term Efficacy of Serenoa repens Treatment in Patients with Mild and Moderate Symptomatic Benign Prostatic Hyperplasia

Sinescu I. · Geavlete P. · Multescu R. · Gangu C. · Miclea F. · Coman I. · Ioiart I. · Ambert V. · Constantin T. · Petrut B. · Feciche B.
aDepartment of Urological Surgery, Dialysis and Kidney Transplantation, Fundeni Clinical Institute, bDepartment of Urology, ‘Saint John’ Clinical Emergency Hospital, and c‘Prof. Dr.Th. Burghele’ Urology Clinical Hospital, Bucharest; dDepartment of Urology, Clinical Emergency Hospital, Timisoara; e‘Vasile Goldis’ University of Medicine, Department of Urology, Arad; fUniversity City Hospital and gOncological Institute ‘Ion Chiricuta’, Cluj, Romania

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/30/2010
Accepted: 10/17/2010
Published online: 2/8/2011

Number of Print Pages: 6
Number of Figures: 5
Number of Tables: 2

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN

Abstract

Introduction: The study aimed to evaluate the long-term efficacy of treatment with extract of Serenoa repens (Prostamol Uno) in patients with lower urinary tract symptoms (LUTS) induced by benign prostatic hyperplasia (BPH). Patients and Methods: We studied 120 patients with mild or moderate LUTS induced by BPH, maximal urinary flow (Qmax) <15 ml with a voided volume ≧150 ml, prostate-specific antigen <4 ng/ml, and residual urinary volume <150 ml, treated daily for 24 months with one capsule of 320 mg ethanolic extract of Serenoa repens. Results: Statistically significant improvements in the International Prostate Symptom Score (5.5 points), quality of life (QoL; 1.8 points), Qmax (5.6 ml/s), International Index of Erectile Function (IIEF; 6.4 points) and reduction in residual urinary volume were observed during the study period. The mean prostate volume at 24 months was 36 ml, compared to 39.8 ml at baseline. Conclusions: Long-term treatment with 320 mg ethanolic extract of Serenoa repens proved to be efficient in reducing urinary obstruction, improving symptomatology and QoL of BPH patients. It also had a positive effect on sexual function, demonstrated by the statistically significant increase in the IIEF.


  

Author Contacts

Petrisor Geavlete
Department of Urology, ‘Saint John’ Clinical Emergency Hospital
Vitan Barzesti 13
RO–042122 Bucharest (Romania)
Tel./Fax +40 21 334 5000, E-Mail geavlete@gmail.com

>

  

Article Information

Received: March 30, 2010
Accepted after revision: October 17, 2010
Published online: February 8, 2011
Number of Print Pages : 6
Number of Figures : 5, Number of Tables : 2, Number of References : 24

  

Publication Details

Urologia Internationalis

Vol. 86, No. 3, Year 2011 (Cover Date: April 2011)

Journal Editor: Wirth M.P. (Dresden), Porena M. (Perugia), Hakenberg O.W. (Rostock), Castro-Diaz D. (Santa Cruz de Tenerife)
ISSN: 0042-1138 (Print), eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/30/2010
Accepted: 10/17/2010
Published online: 2/8/2011

Number of Print Pages: 6
Number of Figures: 5
Number of Tables: 2

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


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